Perinatal cytomegalovirus and toxoplasmosis

Challenges of antepartum therapy

Jeanna M. Piper, Tony S. Wen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Acute maternal toxoplasmosis is associated with increased risk of spontaneous abortion. Congenital toxoplasmosis can present in one of four forms: 1) symptomatic neonatal disease; 2) mild to severe disease manifested within the first month of life; 3) childhood or adolescent sequelae from previously undiagnosed infection; and 4) subclinical infection. The incidence and impact of congenital infection is dependent on the gestational age. The long-term sequelae of congenital toxoplasmosis include seizure disorders, spasticity/palsies, severe visual impairment, hydrocephalus/microcephaly, intracranial calcifications, deafness, and mental retardation. The diagnostic criteria for acute toxoplasmosis include lymphadenopathy, Sabin-Feldman dye test titer greater than 300 IU/ml or ≥ 1:1,000, and a positive IgM-IFA test. The key to preventing congenital infection is the prevention of maternal primary toxoplasmosis infection. Specific hygienic recommendations can prevent maternal infection (primary prevention). Antepartum screening allows consideration of antepartum chemoprophylaxis to reduce fetal infection rates and sequelae (secondary prevention). Antenatal treatment with spiramycin and/or pyrimethamine-sulfonamide can significantly reduce the severity of congenital toxoplasmosis.

Original languageEnglish (US)
Pages (from-to)81-96
Number of pages16
JournalClinical Obstetrics and Gynecology
Volume42
Issue number1
DOIs
StatePublished - Mar 1999
Externally publishedYes

Fingerprint

Toxoplasmosis
Cytomegalovirus
Congenital Toxoplasmosis
Infection
Mothers
Primary Prevention
Infant, Newborn, Diseases
Therapeutics
Spiramycin
Pyrimethamine
Asymptomatic Infections
Vision Disorders
Sulfonamides
Chemoprevention
Deafness
Spontaneous Abortion
Hydrocephalus
Secondary Prevention
Paralysis
Intellectual Disability

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Perinatal cytomegalovirus and toxoplasmosis : Challenges of antepartum therapy. / Piper, Jeanna M.; Wen, Tony S.

In: Clinical Obstetrics and Gynecology, Vol. 42, No. 1, 03.1999, p. 81-96.

Research output: Contribution to journalArticle

Piper, Jeanna M. ; Wen, Tony S. / Perinatal cytomegalovirus and toxoplasmosis : Challenges of antepartum therapy. In: Clinical Obstetrics and Gynecology. 1999 ; Vol. 42, No. 1. pp. 81-96.
@article{d743c4f4a5744ea893e04c72bb63efc0,
title = "Perinatal cytomegalovirus and toxoplasmosis: Challenges of antepartum therapy",
abstract = "Acute maternal toxoplasmosis is associated with increased risk of spontaneous abortion. Congenital toxoplasmosis can present in one of four forms: 1) symptomatic neonatal disease; 2) mild to severe disease manifested within the first month of life; 3) childhood or adolescent sequelae from previously undiagnosed infection; and 4) subclinical infection. The incidence and impact of congenital infection is dependent on the gestational age. The long-term sequelae of congenital toxoplasmosis include seizure disorders, spasticity/palsies, severe visual impairment, hydrocephalus/microcephaly, intracranial calcifications, deafness, and mental retardation. The diagnostic criteria for acute toxoplasmosis include lymphadenopathy, Sabin-Feldman dye test titer greater than 300 IU/ml or ≥ 1:1,000, and a positive IgM-IFA test. The key to preventing congenital infection is the prevention of maternal primary toxoplasmosis infection. Specific hygienic recommendations can prevent maternal infection (primary prevention). Antepartum screening allows consideration of antepartum chemoprophylaxis to reduce fetal infection rates and sequelae (secondary prevention). Antenatal treatment with spiramycin and/or pyrimethamine-sulfonamide can significantly reduce the severity of congenital toxoplasmosis.",
author = "Piper, {Jeanna M.} and Wen, {Tony S.}",
year = "1999",
month = "3",
doi = "10.1097/00003081-199903000-00014",
language = "English (US)",
volume = "42",
pages = "81--96",
journal = "Clinical Obstetrics and Gynecology",
issn = "0009-9201",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Perinatal cytomegalovirus and toxoplasmosis

T2 - Challenges of antepartum therapy

AU - Piper, Jeanna M.

AU - Wen, Tony S.

PY - 1999/3

Y1 - 1999/3

N2 - Acute maternal toxoplasmosis is associated with increased risk of spontaneous abortion. Congenital toxoplasmosis can present in one of four forms: 1) symptomatic neonatal disease; 2) mild to severe disease manifested within the first month of life; 3) childhood or adolescent sequelae from previously undiagnosed infection; and 4) subclinical infection. The incidence and impact of congenital infection is dependent on the gestational age. The long-term sequelae of congenital toxoplasmosis include seizure disorders, spasticity/palsies, severe visual impairment, hydrocephalus/microcephaly, intracranial calcifications, deafness, and mental retardation. The diagnostic criteria for acute toxoplasmosis include lymphadenopathy, Sabin-Feldman dye test titer greater than 300 IU/ml or ≥ 1:1,000, and a positive IgM-IFA test. The key to preventing congenital infection is the prevention of maternal primary toxoplasmosis infection. Specific hygienic recommendations can prevent maternal infection (primary prevention). Antepartum screening allows consideration of antepartum chemoprophylaxis to reduce fetal infection rates and sequelae (secondary prevention). Antenatal treatment with spiramycin and/or pyrimethamine-sulfonamide can significantly reduce the severity of congenital toxoplasmosis.

AB - Acute maternal toxoplasmosis is associated with increased risk of spontaneous abortion. Congenital toxoplasmosis can present in one of four forms: 1) symptomatic neonatal disease; 2) mild to severe disease manifested within the first month of life; 3) childhood or adolescent sequelae from previously undiagnosed infection; and 4) subclinical infection. The incidence and impact of congenital infection is dependent on the gestational age. The long-term sequelae of congenital toxoplasmosis include seizure disorders, spasticity/palsies, severe visual impairment, hydrocephalus/microcephaly, intracranial calcifications, deafness, and mental retardation. The diagnostic criteria for acute toxoplasmosis include lymphadenopathy, Sabin-Feldman dye test titer greater than 300 IU/ml or ≥ 1:1,000, and a positive IgM-IFA test. The key to preventing congenital infection is the prevention of maternal primary toxoplasmosis infection. Specific hygienic recommendations can prevent maternal infection (primary prevention). Antepartum screening allows consideration of antepartum chemoprophylaxis to reduce fetal infection rates and sequelae (secondary prevention). Antenatal treatment with spiramycin and/or pyrimethamine-sulfonamide can significantly reduce the severity of congenital toxoplasmosis.

UR - http://www.scopus.com/inward/record.url?scp=0033396085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033396085&partnerID=8YFLogxK

U2 - 10.1097/00003081-199903000-00014

DO - 10.1097/00003081-199903000-00014

M3 - Article

VL - 42

SP - 81

EP - 96

JO - Clinical Obstetrics and Gynecology

JF - Clinical Obstetrics and Gynecology

SN - 0009-9201

IS - 1

ER -