Perinatal outcomes in hispanic and non-hispanic white women with mild gestational diabetes

Erica K. Berggren, Lisa Mele, Mark B. Landon, Catherine Y. Spong, Susan M. Ramin, Brian Casey, Ronald J. Wapner, Michael W. Varner, Dwight J. Rouse, Anthony Sciscione, Patrick Catalano, Margaret Harper, George Saade, Steve N. Caritis, Yoram Sorokin, Alan M. Peaceman, Jorge E. Tolosa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To compare perinatal outcomes between self-identified Hispanic and non-Hispanic white women with mild gestational diabetes mellitus (GDM) or glucose intolerance. Methods: In a secondary analysis of a mild GDM treatment trial, we compared perinatal outcomes by race and ethnicity for 767 women with glucose intolerance (abnormal 50-g 1-hour screen, normal 100-g 3-hour oral glucose tolerance test), 371 women with mild GDM assigned to usual prenatal care, and 397 women with mild GDM assigned to treatment. Outcomes included: composite adverse perinatal outcome (neonatal death, hypoglycemia, hyperbilirubinemia, hyperinsulinemia, stillbirth, birth trauma), gestational age at delivery, birth weight, and hypertensive disorders of pregnancy. Adjusted regression models included: 100-g 3-hour oral glucose tolerance test results, parity, gestational age, body mass index, maternal age at enrollment, and current tobacco use. Results: The sample of 1,535 women was 68.3% Hispanic and 31.7% non-Hispanic white. Among women with glucose intolerance, Hispanic women had more frequent composite outcome (37% compared with 27%, adjusted odds ratio [OR] 1.62, 95% confidence interval [CI] 1.10-2.37) with more neonatal elevated C-cord peptide (19% compared with 13%, adjusted OR 1.79, 95% CI 1.04-3.08) and neonatal hypoglycemia (21% compared with 13%, adjusted OR 2.04, 95% CI 1.18-3.53). Among women with untreated mild GDM, outcomes were similar by race and ethnicity. Among Hispanic women with treated mild GDM, composite outcome was similar to non-Hispanic white women (35% compared with 25%, adjusted OR 1.62, 95% CI 0.92-2.86), but Hispanic neonates had more frequent hyperinsulinemia (21% compared with 10%, adjusted OR 2.96, 95% CI 1.33-6.60). Conclusion: Individual components of some neonatal outcomes were more frequent in Hispanic neonates, but most perinatal outcomes were similar between Hispanic and non-Hispanic ethnic groups.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalObstetrics and Gynecology
Volume120
Issue number5
DOIs
StatePublished - Nov 2012

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Gestational Diabetes
Hispanic Americans
Odds Ratio
Glucose Intolerance
Confidence Intervals
Hyperinsulinism
Glucose Tolerance Test
Hypoglycemia
Gestational Age
Newborn Infant
Hyperbilirubinemia
Prenatal Care
Stillbirth
Maternal Age
Tobacco Use
Parity
Ethnic Groups
Birth Weight
Body Mass Index
Parturition

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Berggren, E. K., Mele, L., Landon, M. B., Spong, C. Y., Ramin, S. M., Casey, B., ... Tolosa, J. E. (2012). Perinatal outcomes in hispanic and non-hispanic white women with mild gestational diabetes. Obstetrics and Gynecology, 120(5), 1099-1104. https://doi.org/10.1097/AOG.0b013e31827049a5

Perinatal outcomes in hispanic and non-hispanic white women with mild gestational diabetes. / Berggren, Erica K.; Mele, Lisa; Landon, Mark B.; Spong, Catherine Y.; Ramin, Susan M.; Casey, Brian; Wapner, Ronald J.; Varner, Michael W.; Rouse, Dwight J.; Sciscione, Anthony; Catalano, Patrick; Harper, Margaret; Saade, George; Caritis, Steve N.; Sorokin, Yoram; Peaceman, Alan M.; Tolosa, Jorge E.

In: Obstetrics and Gynecology, Vol. 120, No. 5, 11.2012, p. 1099-1104.

Research output: Contribution to journalArticle

Berggren, EK, Mele, L, Landon, MB, Spong, CY, Ramin, SM, Casey, B, Wapner, RJ, Varner, MW, Rouse, DJ, Sciscione, A, Catalano, P, Harper, M, Saade, G, Caritis, SN, Sorokin, Y, Peaceman, AM & Tolosa, JE 2012, 'Perinatal outcomes in hispanic and non-hispanic white women with mild gestational diabetes', Obstetrics and Gynecology, vol. 120, no. 5, pp. 1099-1104. https://doi.org/10.1097/AOG.0b013e31827049a5
Berggren, Erica K. ; Mele, Lisa ; Landon, Mark B. ; Spong, Catherine Y. ; Ramin, Susan M. ; Casey, Brian ; Wapner, Ronald J. ; Varner, Michael W. ; Rouse, Dwight J. ; Sciscione, Anthony ; Catalano, Patrick ; Harper, Margaret ; Saade, George ; Caritis, Steve N. ; Sorokin, Yoram ; Peaceman, Alan M. ; Tolosa, Jorge E. / Perinatal outcomes in hispanic and non-hispanic white women with mild gestational diabetes. In: Obstetrics and Gynecology. 2012 ; Vol. 120, No. 5. pp. 1099-1104.
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abstract = "Objective: To compare perinatal outcomes between self-identified Hispanic and non-Hispanic white women with mild gestational diabetes mellitus (GDM) or glucose intolerance. Methods: In a secondary analysis of a mild GDM treatment trial, we compared perinatal outcomes by race and ethnicity for 767 women with glucose intolerance (abnormal 50-g 1-hour screen, normal 100-g 3-hour oral glucose tolerance test), 371 women with mild GDM assigned to usual prenatal care, and 397 women with mild GDM assigned to treatment. Outcomes included: composite adverse perinatal outcome (neonatal death, hypoglycemia, hyperbilirubinemia, hyperinsulinemia, stillbirth, birth trauma), gestational age at delivery, birth weight, and hypertensive disorders of pregnancy. Adjusted regression models included: 100-g 3-hour oral glucose tolerance test results, parity, gestational age, body mass index, maternal age at enrollment, and current tobacco use. Results: The sample of 1,535 women was 68.3{\%} Hispanic and 31.7{\%} non-Hispanic white. Among women with glucose intolerance, Hispanic women had more frequent composite outcome (37{\%} compared with 27{\%}, adjusted odds ratio [OR] 1.62, 95{\%} confidence interval [CI] 1.10-2.37) with more neonatal elevated C-cord peptide (19{\%} compared with 13{\%}, adjusted OR 1.79, 95{\%} CI 1.04-3.08) and neonatal hypoglycemia (21{\%} compared with 13{\%}, adjusted OR 2.04, 95{\%} CI 1.18-3.53). Among women with untreated mild GDM, outcomes were similar by race and ethnicity. Among Hispanic women with treated mild GDM, composite outcome was similar to non-Hispanic white women (35{\%} compared with 25{\%}, adjusted OR 1.62, 95{\%} CI 0.92-2.86), but Hispanic neonates had more frequent hyperinsulinemia (21{\%} compared with 10{\%}, adjusted OR 2.96, 95{\%} CI 1.33-6.60). Conclusion: Individual components of some neonatal outcomes were more frequent in Hispanic neonates, but most perinatal outcomes were similar between Hispanic and non-Hispanic ethnic groups.",
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AU - Berggren, Erica K.

AU - Mele, Lisa

AU - Landon, Mark B.

AU - Spong, Catherine Y.

AU - Ramin, Susan M.

AU - Casey, Brian

AU - Wapner, Ronald J.

AU - Varner, Michael W.

AU - Rouse, Dwight J.

AU - Sciscione, Anthony

AU - Catalano, Patrick

AU - Harper, Margaret

AU - Saade, George

AU - Caritis, Steve N.

AU - Sorokin, Yoram

AU - Peaceman, Alan M.

AU - Tolosa, Jorge E.

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N2 - Objective: To compare perinatal outcomes between self-identified Hispanic and non-Hispanic white women with mild gestational diabetes mellitus (GDM) or glucose intolerance. Methods: In a secondary analysis of a mild GDM treatment trial, we compared perinatal outcomes by race and ethnicity for 767 women with glucose intolerance (abnormal 50-g 1-hour screen, normal 100-g 3-hour oral glucose tolerance test), 371 women with mild GDM assigned to usual prenatal care, and 397 women with mild GDM assigned to treatment. Outcomes included: composite adverse perinatal outcome (neonatal death, hypoglycemia, hyperbilirubinemia, hyperinsulinemia, stillbirth, birth trauma), gestational age at delivery, birth weight, and hypertensive disorders of pregnancy. Adjusted regression models included: 100-g 3-hour oral glucose tolerance test results, parity, gestational age, body mass index, maternal age at enrollment, and current tobacco use. Results: The sample of 1,535 women was 68.3% Hispanic and 31.7% non-Hispanic white. Among women with glucose intolerance, Hispanic women had more frequent composite outcome (37% compared with 27%, adjusted odds ratio [OR] 1.62, 95% confidence interval [CI] 1.10-2.37) with more neonatal elevated C-cord peptide (19% compared with 13%, adjusted OR 1.79, 95% CI 1.04-3.08) and neonatal hypoglycemia (21% compared with 13%, adjusted OR 2.04, 95% CI 1.18-3.53). Among women with untreated mild GDM, outcomes were similar by race and ethnicity. Among Hispanic women with treated mild GDM, composite outcome was similar to non-Hispanic white women (35% compared with 25%, adjusted OR 1.62, 95% CI 0.92-2.86), but Hispanic neonates had more frequent hyperinsulinemia (21% compared with 10%, adjusted OR 2.96, 95% CI 1.33-6.60). Conclusion: Individual components of some neonatal outcomes were more frequent in Hispanic neonates, but most perinatal outcomes were similar between Hispanic and non-Hispanic ethnic groups.

AB - Objective: To compare perinatal outcomes between self-identified Hispanic and non-Hispanic white women with mild gestational diabetes mellitus (GDM) or glucose intolerance. Methods: In a secondary analysis of a mild GDM treatment trial, we compared perinatal outcomes by race and ethnicity for 767 women with glucose intolerance (abnormal 50-g 1-hour screen, normal 100-g 3-hour oral glucose tolerance test), 371 women with mild GDM assigned to usual prenatal care, and 397 women with mild GDM assigned to treatment. Outcomes included: composite adverse perinatal outcome (neonatal death, hypoglycemia, hyperbilirubinemia, hyperinsulinemia, stillbirth, birth trauma), gestational age at delivery, birth weight, and hypertensive disorders of pregnancy. Adjusted regression models included: 100-g 3-hour oral glucose tolerance test results, parity, gestational age, body mass index, maternal age at enrollment, and current tobacco use. Results: The sample of 1,535 women was 68.3% Hispanic and 31.7% non-Hispanic white. Among women with glucose intolerance, Hispanic women had more frequent composite outcome (37% compared with 27%, adjusted odds ratio [OR] 1.62, 95% confidence interval [CI] 1.10-2.37) with more neonatal elevated C-cord peptide (19% compared with 13%, adjusted OR 1.79, 95% CI 1.04-3.08) and neonatal hypoglycemia (21% compared with 13%, adjusted OR 2.04, 95% CI 1.18-3.53). Among women with untreated mild GDM, outcomes were similar by race and ethnicity. Among Hispanic women with treated mild GDM, composite outcome was similar to non-Hispanic white women (35% compared with 25%, adjusted OR 1.62, 95% CI 0.92-2.86), but Hispanic neonates had more frequent hyperinsulinemia (21% compared with 10%, adjusted OR 2.96, 95% CI 1.33-6.60). Conclusion: Individual components of some neonatal outcomes were more frequent in Hispanic neonates, but most perinatal outcomes were similar between Hispanic and non-Hispanic ethnic groups.

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