Peripapillary retinal nerve fiber layer thickness measurement by three-dimensional optical coherence tomography in a normal population

Mohammad Pakravan, Shila Aramesh, Shahin Yazdani, Mehdi Yaseri, Massih Sedigh-Rahimabadi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Purpose: To determine peripapillary retinal nerve fiber layer (RNFL) thickness values by three-dimensional optical coherence tomography (3D-OCT) in a normal Iranian population and to evaluate the concordance of these measurements with those obtained by the second generation of optical coherence tomography (OCT II). Methods: In a cross-sectional observational study, 96 normal Iranian subjects 20-53 years old were enrolled. Peripapillary RNFL thickness in one randomly selected eye of each subject was measured by 3D-OCT and also by OCT II. Standard achromatic perimetry, corneal pachymetry and A-scan ultrasonographic biometry were also performed. Other study variables included age, gender, laterality (right versus left eye), refractive error, corneal diameter and disc area. Results: Mean peripapillary RNFL thickness measured by 3D-OCT (75.50±8.38) μm was significantly less than that measured by OCT II (144.10±33.32 μm) (P<0.001). Using 3DOCT, no significant difference in peripapillary RNFL thickness was observed by gender (P=0.90) or laterality (P=0.17); RNFL thickness had no correlation with age (P=0.95), axial length (P=0.32), spherical equivalent refractive error (P=0.21), central corneal thickness (P=0.66) and disc area (P=0.31). However, a positive correlation was found between peripapillary RNFL thickness and corneal diameter (P=0.03). Conclusion: 3D-OCT seems to yield lower RNFL thickness values as compared to OCT II. It seems advisable to obtain separate baseline measurements when using different generations of OCT machines.

Original languageEnglish (US)
Pages (from-to)220-227
Number of pages8
JournalJournal of Ophthalmic and Vision Research
Volume4
Issue number4
StatePublished - 2014
Externally publishedYes

Keywords

  • Optical coherence tomography
  • Retinal nerve fiber layer thickness
  • Three-dimensional tomography

ASJC Scopus subject areas

  • Ophthalmology

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