Peripheral excitatory amino acids

Susan M. Carlton

doi:10.1016/S1471-4892(01)00002-9

Peripheral excitatory amino acids

Susan M. Carlton

Neurobiology

Research output: Contribution to journal › Review article › peer-review

153 Scopus citations

Abstract

Glutamate receptors (GluRs) are localized in the periphery on nociceptive primary afferent terminals. Studies in animal models of pain demonstrate that peripheral glutamate is involved in nociceptive transmission in the normal and the inflamed state and that modulation of peripheral GluRs reduces pain behaviors and nociceptor activity. These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin.

Original language	English (US)
Pages (from-to)	52-56
Number of pages	5
Journal	Current Opinion in Pharmacology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/S1471-4892(01)00002-9
State	Published - Feb 1 2001

Keywords

Glutamate
Inflammation
Nociception
Nociceptors
Primary afferents
Sensory neurons
Sympathetic system

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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10.1016/S1471-4892(01)00002-9

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title = "Peripheral excitatory amino acids",

abstract = "Glutamate receptors (GluRs) are localized in the periphery on nociceptive primary afferent terminals. Studies in animal models of pain demonstrate that peripheral glutamate is involved in nociceptive transmission in the normal and the inflamed state and that modulation of peripheral GluRs reduces pain behaviors and nociceptor activity. These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin.",

keywords = "Glutamate, Inflammation, Nociception, Nociceptors, Primary afferents, Sensory neurons, Sympathetic system",

author = "Carlton, {Susan M.}",

note = "Funding Information: The authors thank Vicki Wilson for her excellent secretarial assistance. This work was supported by NIH NS11255, NS27910 and NS40700 to SMC. ",

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T1 - Peripheral excitatory amino acids

AU - Carlton, Susan M.

N1 - Funding Information: The authors thank Vicki Wilson for her excellent secretarial assistance. This work was supported by NIH NS11255, NS27910 and NS40700 to SMC.

PY - 2001/2/1

Y1 - 2001/2/1

N2 - Glutamate receptors (GluRs) are localized in the periphery on nociceptive primary afferent terminals. Studies in animal models of pain demonstrate that peripheral glutamate is involved in nociceptive transmission in the normal and the inflamed state and that modulation of peripheral GluRs reduces pain behaviors and nociceptor activity. These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin.

AB - Glutamate receptors (GluRs) are localized in the periphery on nociceptive primary afferent terminals. Studies in animal models of pain demonstrate that peripheral glutamate is involved in nociceptive transmission in the normal and the inflamed state and that modulation of peripheral GluRs reduces pain behaviors and nociceptor activity. These data provide strong motivation to develop new pharmacological agents that will target peripheral GluRs, offering novel approaches to treatment of pain of peripheral origin.

KW - Glutamate

KW - Inflammation

KW - Nociception

KW - Nociceptors

KW - Primary afferents

KW - Sensory neurons

KW - Sympathetic system

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DO - 10.1016/S1471-4892(01)00002-9

M3 - Review article

C2 - 11712535

AN - SCOPUS:0035258219

SN - 1471-4892

VL - 1

SP - 52

EP - 56

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

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ER -

Peripheral excitatory amino acids

Abstract

Keywords

ASJC Scopus subject areas

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