Peripheral group I metabotropic glutamate receptors modulate nociception in mice

G. Bhave, F. Karim, S. M. Carlton, R. W. Gereau Iv

    Research output: Contribution to journalArticle

    227 Citations (Scopus)

    Abstract

    The metabotropic glutamate receptors (mGluRs) are found throughout the central nervous system, where they modulate neuronal excitability and synaptic transmission. Here we report the presence of phospholipase C-coupled group I mGluRs (mGluR1 and mGluR5) outside the central nervous system on peripheral unmyelinated sensory afferents. Given their localization on predominantly nociceptive afferents, we investigated whether these receptors modulate nociceptive signaling, and found that agonist-induced activation of peripheral group I mGluRs leads to increased sensitivity to noxious heat, a phenomenon termed thermal hyperalgesia. Furthermore, group I mGluR antagonists not only prevent, but also attenuate established formalin-induced pain. Taken together, these results suggest that peripheral mGluRs mediate a component of hyperalgesia and may be therapeutically targeted to prevent and treat inflammatory pain.

    Original languageEnglish (US)
    Pages (from-to)417-423
    Number of pages7
    JournalNature Neuroscience
    Volume4
    Issue number4
    DOIs
    StatePublished - 2001

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    Metabotropic Glutamate Receptors
    Nociception
    Hyperalgesia
    Central Nervous System
    Pain
    Type C Phospholipases
    Synaptic Transmission
    Formaldehyde
    Hot Temperature

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Peripheral group I metabotropic glutamate receptors modulate nociception in mice. / Bhave, G.; Karim, F.; Carlton, S. M.; Gereau Iv, R. W.

    In: Nature Neuroscience, Vol. 4, No. 4, 2001, p. 417-423.

    Research output: Contribution to journalArticle

    Bhave, G, Karim, F, Carlton, SM & Gereau Iv, RW 2001, 'Peripheral group I metabotropic glutamate receptors modulate nociception in mice', Nature Neuroscience, vol. 4, no. 4, pp. 417-423. https://doi.org/10.1038/86075
    Bhave, G. ; Karim, F. ; Carlton, S. M. ; Gereau Iv, R. W. / Peripheral group I metabotropic glutamate receptors modulate nociception in mice. In: Nature Neuroscience. 2001 ; Vol. 4, No. 4. pp. 417-423.
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