Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test

Elyad M. Davidson, Richard E. Coggeshall, Susan M. Carlton

    Research output: Contribution to journalArticle

    189 Citations (Scopus)

    Abstract

    The present study demonstrates that local cutaneous administration of either the N-methyl-D-aspartate (NMDA) glutamate receptor antagonist MK-801 or the non-NMDA glutamate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) significantly attenuates formalin-induced nociceptive behaviors. Specifically, pretreatment with either drug reduced the magnitude and time course of lifting and licking behavior in the late phase of formalin pain; however, flinching behavior was not affected. In contrast, posttreatment of formalin pain with either antagonist did not affect lifting and licking behavior, although flinching behavior was mildly attenuated. We hypothesize that these actions result from blocking of peripheral glutamate receptors located on unmyelinated axons at the dermal-epidermal junction. These data suggest that peripheral glutamate receptors on cutaneous axons can be manipulated to reduce certain aspects of pain of peripheral origin. This route of administration offers the advantage of avoiding the side effects of systemic administration.

    Original languageEnglish (US)
    Pages (from-to)941-946
    Number of pages6
    JournalNeuroReport
    Volume8
    Issue number4
    StatePublished - 1997

    Fingerprint

    D-Aspartic Acid
    Glutamate Receptors
    N-Methylaspartate
    Pain Measurement
    Formaldehyde
    Excitatory Amino Acid Antagonists
    Pain
    Axons
    Cutaneous Administration
    6-Cyano-7-nitroquinoxaline-2,3-dione
    Skin
    Dizocilpine Maleate
    N-Methyl-D-Aspartate Receptors
    aspartic acid receptor
    Pharmaceutical Preparations

    Keywords

    • AMPA
    • CNQX
    • Excitatory amino acids
    • Kainate
    • MK-801

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Davidson, E. M., Coggeshall, R. E., & Carlton, S. M. (1997). Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. NeuroReport, 8(4), 941-946.

    Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. / Davidson, Elyad M.; Coggeshall, Richard E.; Carlton, Susan M.

    In: NeuroReport, Vol. 8, No. 4, 1997, p. 941-946.

    Research output: Contribution to journalArticle

    Davidson, EM, Coggeshall, RE & Carlton, SM 1997, 'Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test', NeuroReport, vol. 8, no. 4, pp. 941-946.
    Davidson, Elyad M. ; Coggeshall, Richard E. ; Carlton, Susan M. / Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test. In: NeuroReport. 1997 ; Vol. 8, No. 4. pp. 941-946.
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