Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia

Eunjoo Baik, Jin Chung, Kyungsoon Chung

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Inflammation of a peripheral nerve (neuritis) causes mechanical and thermal hyperalgesia in the region in which the inflamed nerve innervates. We investigated whether peripherally applied norepinephrine (NE) would exacerbate mechanical hyperalgesia in rats with neuritis. After inflammation of the left L5 spinal nerve with complete Freund's adjuvant, the foot withdrawal thresholds to mechanical stimuli applied to the affected hind paw (mechanical thresholds) were decreased significantly, indicating the development of mechanical hyperalgesia. An intradermal injection of NE to the affected paw further aggravated mechanical hyperalgesia transiently (1-3 days) and then recovered to the pre-NE injection levels afterwards. This responsiveness to NE (adrenergic sensitivity) was observed not only while rats were showing inflammatory hyperalgesia but also after recovering from it. The effect of NE on mechanical hyperalgesia was mediated by both peripheral α1- and α2-adrenoceptors. Immunohistochemical study of the previously inflamed nerve showed that proinflammatory cytokine tumor necrosis factor immunoreactivity was significantly higher in the rats showing adrenergic sensitivity compared to rats without adrenergic sensitivity. The data thus suggest that peripheral NE, when released in an excessive amount from the sympathetic nervous system, might play an important role in the aggravation of pain in neuritis.

Original languageEnglish (US)
Pages (from-to)212-221
Number of pages10
JournalJournal of Pain
Volume4
Issue number4
DOIs
StatePublished - May 2003
Externally publishedYes

Fingerprint

Neuritis
Hyperalgesia
Norepinephrine
Adrenergic Agents
Inflammation
Intradermal Injections
Spinal Nerves
Freund's Adjuvant
Sympathetic Nervous System
Peripheral Nerves
Adrenergic Receptors
Foot
Tumor Necrosis Factor-alpha
Cytokines
Pain
Injections

Keywords

  • CFA
  • Inflammation of nerve
  • Mechanical threshold
  • Proinflammatory cytokine TNF
  • Sympathetically maintained pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia. / Baik, Eunjoo; Chung, Jin; Chung, Kyungsoon.

In: Journal of Pain, Vol. 4, No. 4, 05.2003, p. 212-221.

Research output: Contribution to journalArticle

Baik, Eunjoo ; Chung, Jin ; Chung, Kyungsoon. / Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia. In: Journal of Pain. 2003 ; Vol. 4, No. 4. pp. 212-221.
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