Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero

T. J. Theodoropoulos, M. A. Pappolla, O. S. Goussis, J. C. Zolman, D. M. Benson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.

Original languageEnglish (US)
Pages (from-to)521-523
Number of pages3
JournalHormone and Metabolic Research
Volume22
Issue number10
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Keywords

  • phenytoin and thyroid function
  • phenytoin and thyroid-stimulating hormone
  • phenytoin and thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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