Abstract
Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 521-523 |
| Number of pages | 3 |
| Journal | Hormone and Metabolic Research |
| Volume | 22 |
| Issue number | 10 |
| State | Published - 1990 |
| Externally published | Yes |
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Keywords
- phenytoin and thyroid function
- phenytoin and thyroid-stimulating hormone
- phenytoin and thyrotropin-releasing hormone
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
Cite this
Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero. / Theodoropoulos, T. J.; Pappolla, Miguel; Goussis, O. S.; Zolman, J. C.; Benson, D. M.
In: Hormone and Metabolic Research, Vol. 22, No. 10, 1990, p. 521-523.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero
AU - Theodoropoulos, T. J.
AU - Pappolla, Miguel
AU - Goussis, O. S.
AU - Zolman, J. C.
AU - Benson, D. M.
PY - 1990
Y1 - 1990
N2 - Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.
AB - Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.
KW - phenytoin and thyroid function
KW - phenytoin and thyroid-stimulating hormone
KW - phenytoin and thyrotropin-releasing hormone
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UR - http://www.scopus.com/inward/citedby.url?scp=0025221534&partnerID=8YFLogxK
M3 - Article
C2 - 2079314
AN - SCOPUS:0025221534
VL - 22
SP - 521
EP - 523
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 10
ER -