Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero

T. J. Theodoropoulos; M. A. Pappolla; O. S. Goussis; J. C. Zolman; D. M. Benson

doi:10.1055/s-2007-1004962

Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero

T. J. Theodoropoulos, M. A. Pappolla, O. S. Goussis, J. C. Zolman, D. M. Benson

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.

Original language	English (US)
Pages (from-to)	521-523
Number of pages	3
Journal	Hormone and Metabolic Research
Volume	22
Issue number	10
DOIs	https://doi.org/10.1055/s-2007-1004962
State	Published - 1990
Externally published	Yes

Keywords

phenytoin and thyroid function
phenytoin and thyroid-stimulating hormone
phenytoin and thyrotropin-releasing hormone

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1055/s-2007-1004962

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title = "Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero",

abstract = "Phenytoin exposure in utero results in permanent alterations of the hypothalamic-pituitary-thyroid axis in the rat. The DPH exposed animals have decreased weight gain, thyroxine and triiodothyronine concentrations. In addition, they have blunted thyroid-stimulating hormone responses to thyrotropin-releasing hormone, propylthiouracil challenge or thyroidectomy. The diminished pituitary response in these animals is similar to that reported in neonatal thyrotoxicosis in the rat. This may be due, in part, to structural similarities between phenytoin and the thyroid hormone.",

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AU - Theodoropoulos, T. J.

AU - Pappolla, M. A.

AU - Goussis, O. S.

AU - Zolman, J. C.

AU - Benson, D. M.

PY - 1990

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Permanent alterations in the hypothalamic-pituitary-thyroid axis in the rat following phenytoin exposure in utero

Abstract

Keywords

ASJC Scopus subject areas

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