Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

Keyphrases

• Pathogenic Mechanism 100%
• Conductance 100%
• Membrane Conductance 100%
• Protein Misfolding 100%
• Amyloid-β Oligomers 100%
• Soluble Oligomers 100%
• Permeabilization 100%
• Lipid Bilayer 100%
• Low Molecular Weight 50%
• Disease-related Proteins 50%
• Multi-step Process 50%
• Degenerative Disease 50%
• Amyloid Protein 50%
• Common Mechanisms 50%
• Toxicity Mechanism 50%
• Amyloid Fibrillation 50%
• Ion Selectivity 50%
• Amyloidogenic Peptides 50%
• Protofibrils 50%
• Pore Formation 50%
• Channel Formation 50%
• Co-conformations 50%
• Discrete Channel 50%
• Generic Structure 50%
• Oligomeric Intermediate 50%

Immunology and Microbiology

• Conductance 100%
• Conformation 100%
• Membrane Conductance 100%
• Channel Gating 100%
• Protein Misfolding 100%
• Lipid Bilayer 100%
• Molecular Weight 50%
• Fibril 50%
• Peptides 50%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Protein Misfolding 100%
• Lipid Bilayer 100%
• Amyloid Protein 100%
• Conductance 33%
• Membrane Conductance 33%
• Channel Gating 33%
• Molecular Weight 16%