Permeable tubes increase the length of the gap that regenerating axons can span

Chung Bii Jenq, Richard E. Coggeshall

    Research output: Contribution to journalArticlepeer-review

    99 Scopus citations

    Abstract

    After placement of stumps of transected rat sciatic nerve in an impermeable tube, the maximum gap the axons can span is 10 mm. The present study shows that the regenerating axons cross much longer gaps if the tube is made permeable. This improvement does not require another nerve as a transplant nor the preplacement of extracellular materials in the tube. Possible mechanisms for this improvement are discussed.

    Original languageEnglish (US)
    Pages (from-to)239-242
    Number of pages4
    JournalBrain Research
    Volume408
    Issue number1-2
    DOIs
    StatePublished - Apr 7 1987

    Keywords

    • Axonal regeneration
    • Nerve transection
    • Permeable tube

    ASJC Scopus subject areas

    • General Neuroscience
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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