Abstract
Heart failure is the major cause of hospitalization, morbidity and mortality worldwide. There is considerable evidence suggesting that the increased production of reactive oxygen and nitrogen species play a crucial role in the pathogenesis of various forms of myocardial injury and heart failure. Peroxynitrite, a reactive nitrogen species produced from the diffusion-controlled reaction between nitric oxide and superoxide anion, has been shown to impair cardiac function via multiple mechanisms including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies have demonstrated that pharmacological neutralization of peroxynitrite or inhibition of PARP provides significant benefits in various forms of heart failure. This chapter discusses the role of peroxynitrite and nitrosative stress and downstream pathways in various forms of heart failure.
| Original language | English (US) |
|---|---|
| Title of host publication | Oxidative Stress: Clinical and Biomedical Implications |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 277-290 |
| Number of pages | 14 |
| ISBN (Print) | 9781600218880 |
| State | Published - 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Peroxynitrite and nitrosative stress in heart failure : Role of matrix metalloproteinases (MMPs) and poly(ADP)-ribose polymerase (PARP). / Pacher, Pál; Szabo, Csaba.
Oxidative Stress: Clinical and Biomedical Implications. Nova Science Publishers, Inc., 2007. p. 277-290.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Peroxynitrite and nitrosative stress in heart failure
T2 - Role of matrix metalloproteinases (MMPs) and poly(ADP)-ribose polymerase (PARP)
AU - Pacher, Pál
AU - Szabo, Csaba
PY - 2007
Y1 - 2007
N2 - Heart failure is the major cause of hospitalization, morbidity and mortality worldwide. There is considerable evidence suggesting that the increased production of reactive oxygen and nitrogen species play a crucial role in the pathogenesis of various forms of myocardial injury and heart failure. Peroxynitrite, a reactive nitrogen species produced from the diffusion-controlled reaction between nitric oxide and superoxide anion, has been shown to impair cardiac function via multiple mechanisms including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies have demonstrated that pharmacological neutralization of peroxynitrite or inhibition of PARP provides significant benefits in various forms of heart failure. This chapter discusses the role of peroxynitrite and nitrosative stress and downstream pathways in various forms of heart failure.
AB - Heart failure is the major cause of hospitalization, morbidity and mortality worldwide. There is considerable evidence suggesting that the increased production of reactive oxygen and nitrogen species play a crucial role in the pathogenesis of various forms of myocardial injury and heart failure. Peroxynitrite, a reactive nitrogen species produced from the diffusion-controlled reaction between nitric oxide and superoxide anion, has been shown to impair cardiac function via multiple mechanisms including activation of matrix metalloproteinases (MMPs) and nuclear enzyme poly(ADP-ribose) polymerase (PARP). Recent studies have demonstrated that pharmacological neutralization of peroxynitrite or inhibition of PARP provides significant benefits in various forms of heart failure. This chapter discusses the role of peroxynitrite and nitrosative stress and downstream pathways in various forms of heart failure.
UR - http://www.scopus.com/inward/record.url?scp=84895336352&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895336352&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84895336352
SN - 9781600218880
SP - 277
EP - 290
BT - Oxidative Stress: Clinical and Biomedical Implications
PB - Nova Science Publishers, Inc.
ER -