Abstract
Peroxynitrite - the product of the diffusion-controlled reaction of nitric oxide with superoxide radical - is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 662-680 |
| Number of pages | 19 |
| Journal | Nature Reviews Drug Discovery |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2007 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
Cite this
Peroxynitrite : Biochemistry, pathophysiology and development of therapeutics. / Szabo, Csaba; Ischiropoulos, Harry; Radi, Rafael.
In: Nature Reviews Drug Discovery, Vol. 6, No. 8, 08.2007, p. 662-680.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peroxynitrite
T2 - Biochemistry, pathophysiology and development of therapeutics
AU - Szabo, Csaba
AU - Ischiropoulos, Harry
AU - Radi, Rafael
PY - 2007/8
Y1 - 2007/8
N2 - Peroxynitrite - the product of the diffusion-controlled reaction of nitric oxide with superoxide radical - is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
AB - Peroxynitrite - the product of the diffusion-controlled reaction of nitric oxide with superoxide radical - is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.
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UR - http://www.scopus.com/inward/citedby.url?scp=34547673497&partnerID=8YFLogxK
U2 - 10.1038/nrd2222
DO - 10.1038/nrd2222
M3 - Article
VL - 6
SP - 662
EP - 680
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
SN - 1474-1776
IS - 8
ER -