Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics

Csaba Szabó, Harry Ischiropoulos, Rafael Radi

    Research output: Contribution to journalReview article

    1267 Scopus citations

    Abstract

    Peroxynitrite - the product of the diffusion-controlled reaction of nitric oxide with superoxide radical - is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.

    Original languageEnglish (US)
    Pages (from-to)662-680
    Number of pages19
    JournalNature Reviews Drug Discovery
    Volume6
    Issue number8
    DOIs
    StatePublished - Aug 1 2007

    ASJC Scopus subject areas

    • Pharmacology
    • Drug Discovery

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