Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics

Csaba Szabo, Harry Ischiropoulos, Rafael Radi

Research output: Contribution to journalArticle

1218 Scopus citations

Abstract

Peroxynitrite - the product of the diffusion-controlled reaction of nitric oxide with superoxide radical - is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition of its formation or its decomposition have been shown to be of benefit include vascular diseases, ischaemia-reperfusion injury, circulatory shock, inflammation, pain and neurodegeneration. In this Review, we first discuss the biochemistry and pathophysiology of peroxynitrite and then focus on pharmacological strategies to attenuate the toxic effects of peroxynitrite. These include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)662-680
Number of pages19
JournalNature Reviews Drug Discovery
Volume6
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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