Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

G. S. Scott, L. B. Jakeman, B. T. Stokes, C. Szabó

    Research output: Contribution to journalArticle

    79 Scopus citations

    Abstract

    Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

    Original languageEnglish (US)
    Pages (from-to)120-124
    Number of pages5
    JournalAnnals of Neurology
    Volume45
    Issue number1
    DOIs
    StatePublished - Jan 23 1999

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology

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