Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury

G. S. Scott, L. B. Jakeman, B. T. Stokes, Csaba Szabo

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Peroxynitrite formation and the subsequent activation of the nuclear enzyme, poly (adenosine diphosphate [ADP]-ribose) synthetase (PARS), has been implicated in the pathogenesis of several neurodegenerative disorders. Here, we demonstrate that nitrotyrosine, an indicator of peroxynitrite generation, and poly (ADP) ribose, a marker of PARS activation, were selectively localized within tissues from spinal cord-injured rats. Our data implicate a role for peroxynitrite production and PARS activation in the development of spinal cord trauma.

Original languageEnglish (US)
Pages (from-to)120-124
Number of pages5
JournalAnnals of Neurology
Volume45
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

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Poly Adenosine Diphosphate Ribose
Peroxynitrous Acid
Ligases
Spinal Cord Injuries
Enzyme Activation
Ribose
Neurodegenerative Diseases
Spinal Cord

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Peroxynitrite production and activation of poly (adenosine diphosphate ribose) synthetase in spinal cord injury. / Scott, G. S.; Jakeman, L. B.; Stokes, B. T.; Szabo, Csaba.

In: Annals of Neurology, Vol. 45, No. 1, 1999, p. 120-124.

Research output: Contribution to journalArticle

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