Persistence of anti-NGF induced dorsal root axons: possible penetration into the mammalian spinal cord

Claire E. Hulsebosch, Richard E. Coggeshall, Jose R. Perez-Polo

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Neonatal rats were given daily injections of antisera to nerve growth factor protein (anti-NGF) for a period of 1 month and then allowed to survive 17 more months. The number of neurons in dorsal root ganglia (DRG) and axons in the dorsal root (DR) were determined in the anti-NGF rats and compared to similar numbers from untreated littermates. We found a 32% decrease in DRG neuron number and 32 and 34% increases in myelinated and unmyelinated DR fibers, respectively, in the anti-NGF rats. The sensory cell bodies in the anti-NGF rats were on the average 23% larger than in the normal rats. We conclude that in an NGF deprived environment a population of DRG neurons dies, principally the small neurons, and in response the surviving neurons emit extra processes which persist for most of the life of the rat. This suggests that the anti-NGF induced axons enter the spinal cord and synapse.

Original languageEnglish (US)
Pages (from-to)267-274
Number of pages8
JournalBrain Research
Volume411
Issue number2
DOIs
StatePublished - May 19 1987

Keywords

  • Antibody to nerve growth factor
  • Axonal sprouting
  • Nerve growth factor
  • Unmyelinated axon

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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