Persistence of H7N9 virus antibody response 2 years after infection

Lin Yao; Guo Lin Wang; Li Ling Chen; Cheng Liu; Li Jun Duan; Gregory C. Gray; Mai Juan Ma

doi:10.1111/irv.12702

Persistence of H7N9 virus antibody response 2 years after infection

Lin Yao
, Guo Lin Wang
, Li Ling Chen
, Cheng Liu
, Li Jun Duan
, Gregory C. Gray
, Mai Juan Ma

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7-28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7-51.2) and 73.45 (54.7-106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long-term antibody response at least 2 years after infection.

Original language	English (US)
Pages (from-to)	210-214
Number of pages	5
Journal	Influenza and other respiratory viruses
Volume	14
Issue number	2
DOIs	https://doi.org/10.1111/irv.12702
State	Published - Mar 1 2020
Externally published	Yes

Keywords

H7N9 viruses
antibody response
influenza A virus
persistence
serological

ASJC Scopus subject areas

Epidemiology
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1111/irv.12702

Cite this

@article{7191d856d9e648a4be61af5c52c9c21b,

title = "Persistence of H7N9 virus antibody response 2 years after infection",

abstract = "We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9\%) patients. Three (21.4\%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95\% CI 15.7-28.1), whereas 10 (71.4\%) and all 14 (100\%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95\% CI 25.7-51.2) and 73.45 (54.7-106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long-term antibody response at least 2 years after infection.",

keywords = "H7N9 viruses, antibody response, influenza A virus, persistence, serological",

author = "Lin Yao and Wang, \{Guo Lin\} and Chen, \{Li Ling\} and Cheng Liu and Duan, \{Li Jun\} and Gray, \{Gregory C.\} and Ma, \{Mai Juan\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley \& Sons Ltd.",

year = "2020",

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doi = "10.1111/irv.12702",

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T1 - Persistence of H7N9 virus antibody response 2 years after infection

AU - Yao, Lin

AU - Wang, Guo Lin

AU - Chen, Li Ling

AU - Liu, Cheng

AU - Duan, Li Jun

AU - Gray, Gregory C.

AU - Ma, Mai Juan

PY - 2020/3/1

Y1 - 2020/3/1

N2 - We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7-28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7-51.2) and 73.45 (54.7-106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long-term antibody response at least 2 years after infection.

AB - We measured antibodies against H7N9 virus 2 years after infection in 14 patients who were infected during October 2016-September 2017. Approximately 2 years after infection, antibody titers ≥10 were detectable in 13 (92.9%) patients. Three (21.4%) of 14 patients had hemagglutination inhibition titers ≥40, and their geometric mean titer (GMT) was 20 (95% CI 15.7-28.1), whereas 10 (71.4%) and all 14 (100%) of the 14 patients had titers ≥40, and GMTs at 34.4 (95% CI 25.7-51.2) and 73.45 (54.7-106.7) for neuraminidase inhibition and microneutralization antibodies, respectively. Our findings suggest that H7N9 infection may induce long-term antibody response at least 2 years after infection.

KW - H7N9 viruses

KW - antibody response

KW - influenza A virus

KW - persistence

KW - serological

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