Persistence of rickettsiae in the partially viable gangrenous margins of amputated extremities 5 to 7 weeks after onset of rocky mountain spotted fever

M. G.M. Hove, D. H. Walker

Research output: Contribution to journalArticle

11 Scopus citations


A case of Rocky Mountain spotted fever complicated by gangrene of the extremities required amputation and showed persistent rickettsial infection in the margins of the gangrene at 5 and 7 weeks after onset of illness. Rickettsial organisms were demonstrated by immunoperoxidase staining in the viable endothelial cells in the ischemic margins of the gangrenous tissue. We conclude that the cellular, humoral, and pharmacologic components that lead to eradication of the rickettsiae were not delivered to the ischemic margins at effective antirickettsial concentrations.

Original languageEnglish (US)
Pages (from-to)429-431
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number5
StatePublished - Jan 1 1995


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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