Abstract
Children suffering severe burns develop hypocalcemia, magnesium (Mg) depletion, hypoparathyroidism, and renal resistance to parathyroid hormone (PTH) infusion. We hypothesized that Mg depletion accounted for both the hypoparathyroidism and the renal resistance to PTH, and that Mg repletion would improve both. Due to a lack of PTH for infusion, we studied only the effect of Mg repletion on the relationship between ionized Ca (iCa) and PTH in the serum of 14 sequentially recruited children burned ≥ 40% total body surface area. All received a urinary Mg retention test a median of 20 days post burn (range 8-137 days). Seven (50%) of the children remained Mg depleted, which was not attributable to burn size or to time from burn to study. Combined enteral and parenteral Mg intakes were not different between the depleted and repleted groups, 12.2 ± 4.4 (SD) mg/kg per day and 14.2 ± 6.2 mg/kg per day, respectively. Both groups had low intact PTH levels in relation to serum iCa concentration, indicating persistent hypoparathyroidism. We conclude that Mg depletion is not the chief cause of hypoparathyroidism following thermal injury and we postulate that the persistent hypoparathyroidism is consistent with a reduced set-point for Ca suppression of PTH secretion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 301-304 |
| Number of pages | 4 |
| Journal | Pediatric Nephrology |
| Volume | 14 |
| Issue number | 4 |
| State | Published - Apr 2000 |
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Keywords
- Burns
- Hypocalcemia
- Hypoparathyroidism
- Magnesium
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Persistent hypoparathyroidism following magnesium repletion in burn-injured children. / Klein, Gordon L.; Langman, Craig B.; Herndon, David.
In: Pediatric Nephrology, Vol. 14, No. 4, 04.2000, p. 301-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Persistent hypoparathyroidism following magnesium repletion in burn-injured children
AU - Klein, Gordon L.
AU - Langman, Craig B.
AU - Herndon, David
PY - 2000/4
Y1 - 2000/4
N2 - Children suffering severe burns develop hypocalcemia, magnesium (Mg) depletion, hypoparathyroidism, and renal resistance to parathyroid hormone (PTH) infusion. We hypothesized that Mg depletion accounted for both the hypoparathyroidism and the renal resistance to PTH, and that Mg repletion would improve both. Due to a lack of PTH for infusion, we studied only the effect of Mg repletion on the relationship between ionized Ca (iCa) and PTH in the serum of 14 sequentially recruited children burned ≥ 40% total body surface area. All received a urinary Mg retention test a median of 20 days post burn (range 8-137 days). Seven (50%) of the children remained Mg depleted, which was not attributable to burn size or to time from burn to study. Combined enteral and parenteral Mg intakes were not different between the depleted and repleted groups, 12.2 ± 4.4 (SD) mg/kg per day and 14.2 ± 6.2 mg/kg per day, respectively. Both groups had low intact PTH levels in relation to serum iCa concentration, indicating persistent hypoparathyroidism. We conclude that Mg depletion is not the chief cause of hypoparathyroidism following thermal injury and we postulate that the persistent hypoparathyroidism is consistent with a reduced set-point for Ca suppression of PTH secretion.
AB - Children suffering severe burns develop hypocalcemia, magnesium (Mg) depletion, hypoparathyroidism, and renal resistance to parathyroid hormone (PTH) infusion. We hypothesized that Mg depletion accounted for both the hypoparathyroidism and the renal resistance to PTH, and that Mg repletion would improve both. Due to a lack of PTH for infusion, we studied only the effect of Mg repletion on the relationship between ionized Ca (iCa) and PTH in the serum of 14 sequentially recruited children burned ≥ 40% total body surface area. All received a urinary Mg retention test a median of 20 days post burn (range 8-137 days). Seven (50%) of the children remained Mg depleted, which was not attributable to burn size or to time from burn to study. Combined enteral and parenteral Mg intakes were not different between the depleted and repleted groups, 12.2 ± 4.4 (SD) mg/kg per day and 14.2 ± 6.2 mg/kg per day, respectively. Both groups had low intact PTH levels in relation to serum iCa concentration, indicating persistent hypoparathyroidism. We conclude that Mg depletion is not the chief cause of hypoparathyroidism following thermal injury and we postulate that the persistent hypoparathyroidism is consistent with a reduced set-point for Ca suppression of PTH secretion.
KW - Burns
KW - Hypocalcemia
KW - Hypoparathyroidism
KW - Magnesium
UR - http://www.scopus.com/inward/record.url?scp=0034105494&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034105494&partnerID=8YFLogxK
M3 - Article
C2 - 10775073
AN - SCOPUS:0034105494
VL - 14
SP - 301
EP - 304
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 4
ER -