Persistent infection with West Nile virus years after initial infection

Kristy Murray; Christopher Walker; Emily Herrington; Jessica A. Lewis; Joseph McCormick; David W.C. Beasley; Robert B. Tesh; Susan Fisher-Hoch

doi:10.1086/648731

Persistent infection with West Nile virus years after initial infection

Kristy Murray
, Christopher Walker
, Emily Herrington
, Jessica A. Lewis
, Joseph McCormick
, David W.C. Beasley
, Robert B. Tesh
, Susan Fisher-Hoch

Research output: Contribution to journal › Article › peer-review

199 Scopus citations

Abstract

West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	201
Issue number	1
DOIs	https://doi.org/10.1086/648731
State	Published - Jan 2010

ASJC Scopus subject areas

General Medicine

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10.1086/648731

Cite this

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title = "Persistent infection with West Nile virus years after initial infection",

abstract = "West Nile virus (WNV) RNA was demonstrated in 5 (20\%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99\% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.",

author = "Kristy Murray and Christopher Walker and Emily Herrington and Lewis, \{Jessica A.\} and Joseph McCormick and Beasley, \{David W.C.\} and Tesh, \{Robert B.\} and Susan Fisher-Hoch",

note = "Funding Information: Financial support: This study was funded in part by the National Institutes of Health (NIH) (grants NIH/NIAID/DAIT N01 AI 50027–03 and NIH/NIAID K23 AI057341). Development of the reverse-transcription polymerase chain reaction procedure was supported in part by a grant from the US Department of Defense, Army (grant W81XWH-04-2-0035). R..B.T. and D.W.C.B. were supported by NIH contract N01-A125489. This study was approved by the University of Texas Health Science Center at Houston Committee for the Protection of Human Subjects (grant HSC-SPH-03–039).",

year = "2010",

month = jan,

doi = "10.1086/648731",

language = "English (US)",

volume = "201",

pages = "2--4",

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TY - JOUR

T1 - Persistent infection with West Nile virus years after initial infection

AU - Murray, Kristy

AU - Walker, Christopher

AU - Herrington, Emily

AU - Lewis, Jessica A.

AU - McCormick, Joseph

AU - Beasley, David W.C.

AU - Tesh, Robert B.

AU - Fisher-Hoch, Susan

N1 - Funding Information: Financial support: This study was funded in part by the National Institutes of Health (NIH) (grants NIH/NIAID/DAIT N01 AI 50027–03 and NIH/NIAID K23 AI057341). Development of the reverse-transcription polymerase chain reaction procedure was supported in part by a grant from the US Department of Defense, Army (grant W81XWH-04-2-0035). R..B.T. and D.W.C.B. were supported by NIH contract N01-A125489. This study was approved by the University of Texas Health Science Center at Houston Committee for the Protection of Human Subjects (grant HSC-SPH-03–039).

PY - 2010/1

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N2 - West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.

AB - West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.

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Persistent infection with West Nile virus years after initial infection

Abstract

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