Persistent infections of mammals and mammalian cell cultures with West Nile virus

Shannan Rossi, Peter W. Mason

Research output: Contribution to journalArticle

Abstract

Before 1990, West Nile virus (WNV) was considered to be one of many arthropod-borne viruses that caused mild febrile illness in man. However, in the 1990s, the virus was associated with severe CNS disease that produced mortality in horses and man in Europe. In 1999, WNV was identified as the etiologic agent of an outbreak of human and avian encephalitis in New York City (NY, USA). Like many other Flaviviridae family members, WNV is generally considered to cause acute infections, however, persistent WNV infections have been observed in laboratory-infected animals and in human patients. These persistent infections could be facilitated by changes to the viral genome that allow the virus to evade detection by the host cell, a property that has been studied in cell culture. This review highlights our current knowledge of persistent WNV infections in vitro and in vivo, and speculates on how persistence could influence virus transmission.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalFuture Virology
Volume3
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

West Nile virus
Mammals
Cell Culture Techniques
Infection
Virus Diseases
Viruses
Flaviviridae
Arboviruses
Viral Genome
Central Nervous System Diseases
Laboratory Animals
Encephalitis
Horses
Disease Outbreaks
Fever
Mortality

Keywords

  • Adaptive mutations
  • Flavivirus
  • Immune response
  • Pathogenesis
  • Persistence
  • West Nile virus

ASJC Scopus subject areas

  • Virology

Cite this

Persistent infections of mammals and mammalian cell cultures with West Nile virus. / Rossi, Shannan; Mason, Peter W.

In: Future Virology, Vol. 3, No. 1, 01.2008, p. 25-34.

Research output: Contribution to journalArticle

@article{b337816e09604dc4a83c8aa6219f23ae,
title = "Persistent infections of mammals and mammalian cell cultures with West Nile virus",
abstract = "Before 1990, West Nile virus (WNV) was considered to be one of many arthropod-borne viruses that caused mild febrile illness in man. However, in the 1990s, the virus was associated with severe CNS disease that produced mortality in horses and man in Europe. In 1999, WNV was identified as the etiologic agent of an outbreak of human and avian encephalitis in New York City (NY, USA). Like many other Flaviviridae family members, WNV is generally considered to cause acute infections, however, persistent WNV infections have been observed in laboratory-infected animals and in human patients. These persistent infections could be facilitated by changes to the viral genome that allow the virus to evade detection by the host cell, a property that has been studied in cell culture. This review highlights our current knowledge of persistent WNV infections in vitro and in vivo, and speculates on how persistence could influence virus transmission.",
keywords = "Adaptive mutations, Flavivirus, Immune response, Pathogenesis, Persistence, West Nile virus",
author = "Shannan Rossi and Mason, {Peter W.}",
year = "2008",
month = "1",
doi = "10.2217/17460794.3.1.25",
language = "English (US)",
volume = "3",
pages = "25--34",
journal = "Future Virology",
issn = "1746-0794",
publisher = "Future Medicine Ltd.",
number = "1",

}

TY - JOUR

T1 - Persistent infections of mammals and mammalian cell cultures with West Nile virus

AU - Rossi, Shannan

AU - Mason, Peter W.

PY - 2008/1

Y1 - 2008/1

N2 - Before 1990, West Nile virus (WNV) was considered to be one of many arthropod-borne viruses that caused mild febrile illness in man. However, in the 1990s, the virus was associated with severe CNS disease that produced mortality in horses and man in Europe. In 1999, WNV was identified as the etiologic agent of an outbreak of human and avian encephalitis in New York City (NY, USA). Like many other Flaviviridae family members, WNV is generally considered to cause acute infections, however, persistent WNV infections have been observed in laboratory-infected animals and in human patients. These persistent infections could be facilitated by changes to the viral genome that allow the virus to evade detection by the host cell, a property that has been studied in cell culture. This review highlights our current knowledge of persistent WNV infections in vitro and in vivo, and speculates on how persistence could influence virus transmission.

AB - Before 1990, West Nile virus (WNV) was considered to be one of many arthropod-borne viruses that caused mild febrile illness in man. However, in the 1990s, the virus was associated with severe CNS disease that produced mortality in horses and man in Europe. In 1999, WNV was identified as the etiologic agent of an outbreak of human and avian encephalitis in New York City (NY, USA). Like many other Flaviviridae family members, WNV is generally considered to cause acute infections, however, persistent WNV infections have been observed in laboratory-infected animals and in human patients. These persistent infections could be facilitated by changes to the viral genome that allow the virus to evade detection by the host cell, a property that has been studied in cell culture. This review highlights our current knowledge of persistent WNV infections in vitro and in vivo, and speculates on how persistence could influence virus transmission.

KW - Adaptive mutations

KW - Flavivirus

KW - Immune response

KW - Pathogenesis

KW - Persistence

KW - West Nile virus

UR - http://www.scopus.com/inward/record.url?scp=38049184463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049184463&partnerID=8YFLogxK

U2 - 10.2217/17460794.3.1.25

DO - 10.2217/17460794.3.1.25

M3 - Article

AN - SCOPUS:38049184463

VL - 3

SP - 25

EP - 34

JO - Future Virology

JF - Future Virology

SN - 1746-0794

IS - 1

ER -