Persistent shedding of West Nile virus in urine of experimentally infected hamsters

Jessica H. Tonry; Shu Yuan Xiao; Marina Siirin; Hongli Chen; Amelia P.A. Travassos Da Rosa; Robert B. Tesh

doi:10.4269/ajtmh.2005.72.320

Persistent shedding of West Nile virus in urine of experimentally infected hamsters

Jessica H. Tonry, Shu Yuan Xiao, Marina Siirin, Hongli Chen, Amelia P.A. Travassos Da Rosa, Robert B. Tesh

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.

Original language	English (US)
Pages (from-to)	320-324
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	72
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.2005.72.320
State	Published - Mar 2005
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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10.4269/ajtmh.2005.72.320

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abstract = "Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.",

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AU - Tonry, Jessica H.

AU - Xiao, Shu Yuan

AU - Siirin, Marina

AU - Chen, Hongli

AU - Travassos Da Rosa, Amelia P.A.

AU - Tesh, Robert B.

PY - 2005/3

Y1 - 2005/3

N2 - Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.

AB - Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidemiologic importance are discussed.

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Persistent shedding of West Nile virus in urine of experimentally infected hamsters

Abstract

ASJC Scopus subject areas

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