Person-to-person transmission of Nipah virus in a Bangladeshi community

Emily S. Gurley, Joel M. Montgomery, M. Jahangir Hossain, Michael Bell, Abul Kalam Azad, Mohammed Rafiqul Islam, Mohammed Abdur Rahim Molla, Darin S. Carroll, Thomas Ksiazek, Paul A. Rota, Luis Lowe, James A. Comer, Pierre Rollin, Markus Czub, Allen Grolla, Heinz Feldmann, Stephen P. Luby, Jennifer L. Woodward, Robert F. Breiman

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April-May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9-16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings.

Original languageEnglish (US)
Pages (from-to)1031-1037
Number of pages7
JournalEmerging Infectious Diseases
Volume13
Issue number7
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

Nipah Virus
Reverse Transcription
Disease Outbreaks
Polymerase Chain Reaction
Bangladesh
Encephalitis
Infection Control
Case-Control Studies
Odds Ratio
Confidence Intervals
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Gurley, E. S., Montgomery, J. M., Hossain, M. J., Bell, M., Azad, A. K., Islam, M. R., ... Breiman, R. F. (2007). Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerging Infectious Diseases, 13(7), 1031-1037.

Person-to-person transmission of Nipah virus in a Bangladeshi community. / Gurley, Emily S.; Montgomery, Joel M.; Hossain, M. Jahangir; Bell, Michael; Azad, Abul Kalam; Islam, Mohammed Rafiqul; Molla, Mohammed Abdur Rahim; Carroll, Darin S.; Ksiazek, Thomas; Rota, Paul A.; Lowe, Luis; Comer, James A.; Rollin, Pierre; Czub, Markus; Grolla, Allen; Feldmann, Heinz; Luby, Stephen P.; Woodward, Jennifer L.; Breiman, Robert F.

In: Emerging Infectious Diseases, Vol. 13, No. 7, 07.2007, p. 1031-1037.

Research output: Contribution to journalArticle

Gurley, ES, Montgomery, JM, Hossain, MJ, Bell, M, Azad, AK, Islam, MR, Molla, MAR, Carroll, DS, Ksiazek, T, Rota, PA, Lowe, L, Comer, JA, Rollin, P, Czub, M, Grolla, A, Feldmann, H, Luby, SP, Woodward, JL & Breiman, RF 2007, 'Person-to-person transmission of Nipah virus in a Bangladeshi community', Emerging Infectious Diseases, vol. 13, no. 7, pp. 1031-1037.
Gurley ES, Montgomery JM, Hossain MJ, Bell M, Azad AK, Islam MR et al. Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerging Infectious Diseases. 2007 Jul;13(7):1031-1037.
Gurley, Emily S. ; Montgomery, Joel M. ; Hossain, M. Jahangir ; Bell, Michael ; Azad, Abul Kalam ; Islam, Mohammed Rafiqul ; Molla, Mohammed Abdur Rahim ; Carroll, Darin S. ; Ksiazek, Thomas ; Rota, Paul A. ; Lowe, Luis ; Comer, James A. ; Rollin, Pierre ; Czub, Markus ; Grolla, Allen ; Feldmann, Heinz ; Luby, Stephen P. ; Woodward, Jennifer L. ; Breiman, Robert F. / Person-to-person transmission of Nipah virus in a Bangladeshi community. In: Emerging Infectious Diseases. 2007 ; Vol. 13, No. 7. pp. 1031-1037.
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