Personalization of loco-regional care for primary breast cancer patients (part 2)

Masakazu Toi; Eric P. Winer; John R. Benson; Takashi Inamoto; John F. Forbes; Gunter Von Minckwitz; John Fr Robertson; Stephen R. Grobmyer; Ismail Jatoi; Hironobu Sasano; Ian Kunkler; Alice Y. Ho; Chikako Yamauchi; Louis Wc Chow; Chiun Sheng Huang; Wonshik Han; Shinzaburo Noguchi; Mark D. Pegram; Hideko Yamauchi; Eun Sook Lee; Alexey A. Larionov; Jose Lb Bevilacqua; Michio Yoshimura; Tomoharu Sugie; Akira Yamauchi; Ian E. Krop; Dong Young Noh; V. Suzanne Klimberg

doi:10.2217/fon.15.66

Personalization of loco-regional care for primary breast cancer patients (part 2)

Masakazu Toi, Eric P. Winer, John R. Benson, Takashi Inamoto, John F. Forbes, Gunter Von Minckwitz, John Fr Robertson, Stephen R. Grobmyer, Ismail Jatoi, Hironobu Sasano, Ian Kunkler, Alice Y. Ho, Chikako Yamauchi, Louis Wc Chow, Chiun Sheng Huang, Wonshik Han, Shinzaburo Noguchi, Mark D. Pegram, Hideko Yamauchi, Eun Sook LeeAlexey A. Larionov, Jose Lb Bevilacqua, Michio Yoshimura, Tomoharu Sugie, Akira Yamauchi, Ian E. Krop, Dong Young Noh, V. Suzanne Klimberg

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer susceptibility. Personalization of loco-regional treatment is integral to optimization of breast cancer care. Clinical and pathological tumor stage, biological features and host factors influence loco-regional treatment strategies and extent of surgical procedures. Key issues including axillary staging, axillary treatment, radiation therapy, primary systemic therapy (PST), preoperative hormonal therapy and genetic predisposition were identified and discussed at the Kyoto Breast Cancer Consensus Conference (KBCCC2014). In the second of a two part conference scene, consensus recommendations for radiation treatment, primary systemic therapies and management of genetic predisposition are reported and focus on the following topics: influence of both clinical response to PST and stage at presentation on recommendations for postmastectomy radiotherapy; use of regional nodal irradiation in selected node-positive patients and those with adverse pathological factors; extent of surgical resection following downstaging of tumors with PST; use of preoperative hormonal therapy in premenopausal women with larger, node-negative luminal A-like tumors and managing increasing demands for contralateral prophylactic mastectomy in patients with a unilateral sporadic breast cancer.

Original language	English (US)
Pages (from-to)	1301-1305
Number of pages	5
Journal	Future Oncology
Volume	11
Issue number	9
DOIs	https://doi.org/10.2217/fon.15.66
State	Published - May 1 2015
Externally published	Yes

Keywords

BRCA1/2
breast cancer
luminal type
postmastectomy radiation therapy

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon.15.66

Cite this

Toi, M., Winer, E. P., Benson, J. R., Inamoto, T., Forbes, J. F., Von Minckwitz, G., Robertson, J. F., Grobmyer, S. R., Jatoi, I., Sasano, H., Kunkler, I., Ho, A. Y., Yamauchi, C., Chow, L. W., Huang, C. S., Han, W., Noguchi, S., Pegram, M. D., Yamauchi, H., ... Klimberg, V. S. (2015). Personalization of loco-regional care for primary breast cancer patients (part 2). Future Oncology, 11(9), 1301-1305. https://doi.org/10.2217/fon.15.66

Toi, M, Winer, EP, Benson, JR, Inamoto, T, Forbes, JF, Von Minckwitz, G, Robertson, JF, Grobmyer, SR, Jatoi, I, Sasano, H, Kunkler, I, Ho, AY, Yamauchi, C, Chow, LW, Huang, CS, Han, W, Noguchi, S, Pegram, MD, Yamauchi, H, Lee, ES, Larionov, AA, Bevilacqua, JL, Yoshimura, M, Sugie, T, Yamauchi, A, Krop, IE, Noh, DY & Klimberg, VS 2015, 'Personalization of loco-regional care for primary breast cancer patients (part 2)', Future Oncology, vol. 11, no. 9, pp. 1301-1305. https://doi.org/10.2217/fon.15.66

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title = "Personalization of loco-regional care for primary breast cancer patients (part 2)",

abstract = "The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer susceptibility. Personalization of loco-regional treatment is integral to optimization of breast cancer care. Clinical and pathological tumor stage, biological features and host factors influence loco-regional treatment strategies and extent of surgical procedures. Key issues including axillary staging, axillary treatment, radiation therapy, primary systemic therapy (PST), preoperative hormonal therapy and genetic predisposition were identified and discussed at the Kyoto Breast Cancer Consensus Conference (KBCCC2014). In the second of a two part conference scene, consensus recommendations for radiation treatment, primary systemic therapies and management of genetic predisposition are reported and focus on the following topics: influence of both clinical response to PST and stage at presentation on recommendations for postmastectomy radiotherapy; use of regional nodal irradiation in selected node-positive patients and those with adverse pathological factors; extent of surgical resection following downstaging of tumors with PST; use of preoperative hormonal therapy in premenopausal women with larger, node-negative luminal A-like tumors and managing increasing demands for contralateral prophylactic mastectomy in patients with a unilateral sporadic breast cancer.",

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year = "2015",

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doi = "10.2217/fon.15.66",

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AU - Forbes, John F.

AU - Von Minckwitz, Gunter

AU - Robertson, John Fr

AU - Grobmyer, Stephen R.

AU - Jatoi, Ismail

AU - Sasano, Hironobu

AU - Kunkler, Ian

AU - Ho, Alice Y.

AU - Yamauchi, Chikako

AU - Chow, Louis Wc

AU - Huang, Chiun Sheng

AU - Han, Wonshik

AU - Noguchi, Shinzaburo

AU - Pegram, Mark D.

AU - Yamauchi, Hideko

AU - Lee, Eun Sook

AU - Larionov, Alexey A.

AU - Bevilacqua, Jose Lb

AU - Yoshimura, Michio

AU - Sugie, Tomoharu

AU - Yamauchi, Akira

AU - Krop, Ian E.

AU - Noh, Dong Young

AU - Klimberg, V. Suzanne

PY - 2015/5/1

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N2 - The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer susceptibility. Personalization of loco-regional treatment is integral to optimization of breast cancer care. Clinical and pathological tumor stage, biological features and host factors influence loco-regional treatment strategies and extent of surgical procedures. Key issues including axillary staging, axillary treatment, radiation therapy, primary systemic therapy (PST), preoperative hormonal therapy and genetic predisposition were identified and discussed at the Kyoto Breast Cancer Consensus Conference (KBCCC2014). In the second of a two part conference scene, consensus recommendations for radiation treatment, primary systemic therapies and management of genetic predisposition are reported and focus on the following topics: influence of both clinical response to PST and stage at presentation on recommendations for postmastectomy radiotherapy; use of regional nodal irradiation in selected node-positive patients and those with adverse pathological factors; extent of surgical resection following downstaging of tumors with PST; use of preoperative hormonal therapy in premenopausal women with larger, node-negative luminal A-like tumors and managing increasing demands for contralateral prophylactic mastectomy in patients with a unilateral sporadic breast cancer.

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Personalization of loco-regional care for primary breast cancer patients (part 2)

Abstract

Keywords

ASJC Scopus subject areas

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