Perspectives on neonatal hypoxia/ischemia-induced edema formation

Diana Carolina Ferrari, Olivera Nesic, Jose Regino Perez-Polo

    Research output: Contribution to journalArticle

    15 Scopus citations

    Abstract

    Neonatal hypoxia/ischemia (HI) is the most common cause of developmental neurological, cognitive and behavioral deficits in children, with hyperoxia (HHI) treatment being a clinical therapy for newborn resuscitation. Although cerebral edema is a common outcome after HI, the mechanisms leading to excessive fluid accumulation in the brain are poorly understood. Given the rigid nature of the bone-encased brain matter, knowledge of edema formation in the brain as a consequence of any injury, as well as the importance of water clearance mechanisms and water and ion homeostasis is important to our understanding of its detrimental effects. Knowledge of the pathological process underlying the appearance of dysfunctional outcomes after development of cerebral edema after neonatal HI in the developing brain and the molecular events triggered will allow a rational assessment of HHI therapy for neonatal HI and determine whether this treatment is beneficial or harmful to the developing infant.

    Original languageEnglish (US)
    Pages (from-to)1957-1965
    Number of pages9
    JournalNeurochemical Research
    Volume35
    Issue number12
    DOIs
    StatePublished - Dec 2010

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    Keywords

    • AQP4 protein
    • Edema
    • Hyperoxia
    • Hypoxia ischemia
    • Perinatal ischemia

    ASJC Scopus subject areas

    • Cellular and Molecular Neuroscience
    • Biochemistry

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