Perspectives on the formation of radiation-induced exchange aberrations

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Controversy surrounding the proposed mechanism of radiation-induced translocation has existed virtually since the inception of radiation genetics/cytogenetics, some 75 years ago. Chief among these controversies is how close chromosomes have to be to one another at the time of exposure for an exchange to occur. An historically related issue, and one that continues to generate lively debate, is whether both chromosomes participating in an exchange must sustain radiation damage, or whether instead a single damaged site on one chromosome is sufficient. The intent of this paper is to present one person's perspective as we revisit these two long-standing issues, armed with more recent knowledge in three key areas. These include a new-found appreciation for the complexity of chromosome rearrangements; molecular processes of recombination that are likely to be involved; and the architecture of the nucleus regarding the relationship among chromosomes during interphase.

Original languageEnglish (US)
Pages (from-to)1182-1191
Number of pages10
JournalDNA Repair
Volume5
Issue number9-10
DOIs
StatePublished - Sep 8 2006

Keywords

  • Chromosome aberrations
  • Interphase domains
  • Ionizing radiation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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