TY - JOUR
T1 - Perspectives on the formation of radiation-induced exchange aberrations
AU - Cornforth, Michael N.
N1 - Funding Information:
The author is indebted to J.R.K. Savage for helpful discussion, especially regarding key historical aspects. This work was funded by the Office of Science (BER), US Department of Energy, Grant No. DE-FG03-02ER63442 and the National Aeronautical and Space Administration Office of Biological and Physical Research (NASA/OBPR).
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006/9/8
Y1 - 2006/9/8
N2 - Controversy surrounding the proposed mechanism of radiation-induced translocation has existed virtually since the inception of radiation genetics/cytogenetics, some 75 years ago. Chief among these controversies is how close chromosomes have to be to one another at the time of exposure for an exchange to occur. An historically related issue, and one that continues to generate lively debate, is whether both chromosomes participating in an exchange must sustain radiation damage, or whether instead a single damaged site on one chromosome is sufficient. The intent of this paper is to present one person's perspective as we revisit these two long-standing issues, armed with more recent knowledge in three key areas. These include a new-found appreciation for the complexity of chromosome rearrangements; molecular processes of recombination that are likely to be involved; and the architecture of the nucleus regarding the relationship among chromosomes during interphase.
AB - Controversy surrounding the proposed mechanism of radiation-induced translocation has existed virtually since the inception of radiation genetics/cytogenetics, some 75 years ago. Chief among these controversies is how close chromosomes have to be to one another at the time of exposure for an exchange to occur. An historically related issue, and one that continues to generate lively debate, is whether both chromosomes participating in an exchange must sustain radiation damage, or whether instead a single damaged site on one chromosome is sufficient. The intent of this paper is to present one person's perspective as we revisit these two long-standing issues, armed with more recent knowledge in three key areas. These include a new-found appreciation for the complexity of chromosome rearrangements; molecular processes of recombination that are likely to be involved; and the architecture of the nucleus regarding the relationship among chromosomes during interphase.
KW - Chromosome aberrations
KW - Interphase domains
KW - Ionizing radiation
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U2 - 10.1016/j.dnarep.2006.05.008
DO - 10.1016/j.dnarep.2006.05.008
M3 - Article
C2 - 16807139
AN - SCOPUS:33747872052
SN - 1568-7864
VL - 5
SP - 1182
EP - 1191
JO - DNA Repair
JF - DNA Repair
IS - 9-10
ER -