Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia

Houssam Attoui, Maria Rosario Mendez-lopez, Shujing Rao, Ana Hurtado-Alendes, Frank Lizaraso-Caparo, Fauziah Mohd Jaafar, Alan R. Samuel, Mourad Belhouchet, Lindsay I. Pritchard, Lorna Melville, Richard P. Weir, Alex D. Hyatt, Steven S. Davis, Ross Lunt, Charles H. Calisher, Robert B. Tesh, Ricardo Fujita, Peter P C Mertens

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

During 1997, two new viruses were isolated from outbreaks of disease that occurred in horses, donkeys, cattle and sheep in Peru. Genome characterization showed that the virus isolated from horses (with neurological disorders, 78% fatality) belongs to a new species the Peruvian horse sickness virus (PHSV), within the genus Orbivirus, family Reoviridae. This represents the first isolation of PHSV, which was subsequently also isolated during 1999, from diseased horses in the Northern Territory of Australia (Elsey virus, ELSV). Serological and molecular studies showed that PHSV and ELSV are very similar in the serotype-determining protein (99%, same serotype). The second virus (Rioja virus, RIOV) was associated with neurological signs in donkeys, cattle, sheep and dogs and was shown to be a member of the species Yunnan orbivirus (YUOV). RIOV and YUOV are also almost identical (97% amino acid identity) in the serotype-determining protein. YUOV was originally isolated from mosquitoes in China.

Original languageEnglish (US)
Pages (from-to)298-310
Number of pages13
JournalVirology
Volume394
Issue number2
DOIs
StatePublished - Nov 25 2009

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Keywords

  • Australia
  • China
  • Emerging viruses
  • Neurological signs
  • Orbivirus
  • Peru
  • Peruvian horse sickness
  • Reoviridae
  • Yunnan orbivirus

ASJC Scopus subject areas

  • Virology

Cite this

Attoui, H., Mendez-lopez, M. R., Rao, S., Hurtado-Alendes, A., Lizaraso-Caparo, F., Jaafar, F. M., Samuel, A. R., Belhouchet, M., Pritchard, L. I., Melville, L., Weir, R. P., Hyatt, A. D., Davis, S. S., Lunt, R., Calisher, C. H., Tesh, R. B., Fujita, R., & Mertens, P. P. C. (2009). Peruvian horse sickness virus and Yunnan orbivirus, isolated from vertebrates and mosquitoes in Peru and Australia. Virology, 394(2), 298-310. https://doi.org/10.1016/j.virol.2009.08.032