TY - JOUR
T1 - PET/MR in invasive ductal breast cancer
T2 - Correlation between imaging markers and histological phenotype
AU - Catalano, Onofrio Antonio
AU - Horn, Gary Lloyd
AU - Signore, Alberto
AU - Iannace, Carlo
AU - Lepore, Maria
AU - Vangel, Mark
AU - Luongo, Angelo
AU - Catalano, Marco
AU - Lehman, Constance
AU - Salvatore, Marco
AU - Soricelli, Andrea
AU - Catana, Ciprian
AU - Mahmood, Umar
AU - Rosen, Bruce Robert
N1 - Publisher Copyright:
© 2017 Cancer Research UK. All rights reserved.
PY - 2017/3/28
Y1 - 2017/3/28
N2 - Background:Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes.Methods:21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR. Magnetic resonance-perfusion biomarkers, apparent diffusion coefficient (ADC), and standard uptake value (SUV) were compared with IHC markers and phenotypes, using a Student's t-test and one-way ANOVA.Results:ER/PR-tumours demonstrated higher Kep mean and SUV max than ER or PR+ tumours. HER2-tumours displayed higher ADC mean, Kep mean, and SUV max than HER2+tumours. Only ADC mean discriminated Ki67≤14% tumours (lower ADC mean) from Ki67>14% tumours. PET/MR biomarkers correlated with IHC phenotype in 13 out of 21 patients (62%; P=0.001).Conclusions:Positron emission tomography magnetic resonance might non-invasively help discriminate IDC phenotypes, helping to optimise individual therapy options.
AB - Background:Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes.Methods:21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR. Magnetic resonance-perfusion biomarkers, apparent diffusion coefficient (ADC), and standard uptake value (SUV) were compared with IHC markers and phenotypes, using a Student's t-test and one-way ANOVA.Results:ER/PR-tumours demonstrated higher Kep mean and SUV max than ER or PR+ tumours. HER2-tumours displayed higher ADC mean, Kep mean, and SUV max than HER2+tumours. Only ADC mean discriminated Ki67≤14% tumours (lower ADC mean) from Ki67>14% tumours. PET/MR biomarkers correlated with IHC phenotype in 13 out of 21 patients (62%; P=0.001).Conclusions:Positron emission tomography magnetic resonance might non-invasively help discriminate IDC phenotypes, helping to optimise individual therapy options.
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U2 - 10.1038/bjc.2017.26
DO - 10.1038/bjc.2017.26
M3 - Article
C2 - 28208155
AN - SCOPUS:85013073372
SN - 0007-0920
VL - 116
SP - 893
EP - 902
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 7
ER -