Pfannenstiel versus Vertical Skin Incision for Cesarean Delivery in Women with Class III Obesity: A Randomized Trial

Caroline Marrs, Sean Blackwell, Ashley Hester, Gayle Olson, George R. Saade, Jonathan Faro, Claudia Pedroza, Baha Sibai

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective To compare Pfannenstiel versus vertical skin incision for the prevention of cesarean wound complications in morbidly obese women. Study Design Women with body mass index ≥ 40 kg/m 2 undergoing cesarean delivery (CD) were randomly allocated to Pfannenstiel or vertical skin incision. The primary outcome was a wound complication within 6 weeks. Due to a low consent rate, we limited enrollment to a defined time period for feasibility. We conducted a traditional frequentist analysis with log-binomial regression to obtain relative risks (RRs), and a Bayesian analysis to estimate the probability of treatment benefit. A priori, we decided that a ≥60% probability of treatment benefit for either incision type would be convincing evidence to pursue a larger trial. Results A total of 648 women were approached, 228 were consented, and 91 were randomized. The primary outcome rate was 19% in the Pfannenstiel group and 21% in the vertical group (RR: 1.18; 95% confidence interval: 0.49-2.85). Bayesian analysis revealed a 59% probability that Pfannenstiel had a lower primary outcome rate. Conclusion In the first published randomized trial to compare skin incision types for obese women undergoing CD, we were unable to demonstrate differences in clinical outcomes. Our trial suggests that a larger study would have a low probability for different findings. Trial Registration NCT 01897376 (www.clinicaltrials.gov).

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalAmerican Journal of Perinatology
Volume36
Issue number1
DOIs
StatePublished - 2019

Keywords

  • Pfannenstiel
  • cesarean
  • complication
  • obesity
  • skin incision
  • transverse
  • vertical
  • wound infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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