pH modulates the vestibular afferent discharge and its response to excitatory amino acids

Rosario Vega, Francisco Mercado, Hortencia Chávez, Agenor Limon-Ruiz, Angélica Almanza, Aída Ortega, Ma Eugenia Pérez, Enrique Soto

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In the isolated inner ear of the axolotl (Ambystoma tigrinum) acid pH decreased and basic pH increased the resting and mechanically evoked spike discharge of semicircular canal afferent neurons. Variations in pH also modified the afferent neuron response to N-methyl-D-aspartic acid (NMDA) acid and to (±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA). Responses to both excitatory amino acid agonists increased at pH 7.8 (41% and 22%, respectively) and decreased by perfusion of the preparation with a saline solution, of pH 7.0 (28% in both cases). These results indicate that vestibular endorgans have a significant sensitivity to pH that could play a significant role in various pathological states, and may also contribute to the post-transductional processing of sensory information.

Original languageEnglish (US)
Pages (from-to)1327-1328
Number of pages2
JournalNeuroReport
Volume14
Issue number10
DOIs
StatePublished - Jul 18 2003
Externally publishedYes

Keywords

  • AMPA
  • Cochlear implant
  • Hair cell
  • Neuromodulation
  • NMDA
  • PH
  • Proton
  • Semicircular canal
  • Vestibular implant

ASJC Scopus subject areas

  • Neuroscience(all)

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    Vega, R., Mercado, F., Chávez, H., Limon-Ruiz, A., Almanza, A., Ortega, A., Pérez, M. E., & Soto, E. (2003). pH modulates the vestibular afferent discharge and its response to excitatory amino acids. NeuroReport, 14(10), 1327-1328. https://doi.org/10.1097/00001756-200307180-00008