Pharmacognostic investigation, acute toxicity studies and isolation of steroidal compound from the leaves of Cassia fistula Linn

Tejendra Bhakta, Prashanta Kr Deb, Kaushik Nath Bhaumik, Joydip Saha

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Pharmacognostic, phytochemical and acute toxicity studies of Cassia fistula leaves were performed which led to the isolation of a steroidal compound (β-sitosterol) and reported for the first time from this plant. The structure of the compound established on the basis of extensive spectroscopic analysis including UV spectra, IR spectra, 1H- NMR spectra, Mass spectral data. All the pharmacognostic experimental evidences conclusively prove the identity and quality of the leaves of Cassia fistula Linn. The acute toxicity of different extracts on animal models has also been studied to access the minimum lethal dose (MLD). All the spectroscopic data were compared with the β-sitosterol and found matched.

Original languageEnglish (US)
Article number36
Pages (from-to)210-214
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume25
Issue number1
StatePublished - 2014
Externally publishedYes

Keywords

  • Acute-toxicity study
  • Cassia fistula leaves
  • Pharmacognostic parameters
  • Phytochemical investigation
  • β-sitosterol

ASJC Scopus subject areas

  • Pharmaceutical Science

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