Pharmacokinetic and pharmacodynamic evaluation of sublingual sufentanil in the treatment of post-operative pain

Rovnat Babazade, Alparslan Turan

Research output: Contribution to journalArticle

4 Scopus citations


Introduction: Intravenous patient-controlled analgesia using opioids is frequently used to provide perioperative analgesia. However, there are a number of drawbacks for intravenous patient-controlled analgesia. The sufentanil sublingual tablet system is a major evolution in technology and drug development for postoperative pain management.Areas Covered: We reviewed the use of sublingual sufentanil in postoperative pain management, with a focus on chemistry, pharmacokinetics and clinical use in different surgical patients.Expert Opinion: The sufentanil sublingual tablet system can decrease intravenous patient-controlled analgesia-related safety issues. Current clinical studies have demonstrated this novel system to be safe and effective in postoperative pain management.

Original languageEnglish (US)
Pages (from-to)217-224
Number of pages8
JournalExpert Opinion on Drug Metabolism and Toxicology
Issue number2
StatePublished - Feb 1 2016



  • Patient-controlled analgesia
  • postoperative pain
  • sublingual sufentanil treatment system
  • sufentanil
  • sufentanil metabolism

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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