Abstract
Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-224 |
| Number of pages | 12 |
| Journal | Best Practice and Research: Clinical Anaesthesiology |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2009 |
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Keywords
- anaesthesia
- anaesthetics
- biological
- blood pressure
- body weight
- cardiac output
- colouring agents
- fluid therapy
- haemoglobins
- heart rate
- humans
- indocyanine green
- inhalation
- isoflurane
- models
- population
- sodium chloride
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Pharmacokinetic aspects of fluid therapy. / Svensen, Christer H.; Rodhe, Peter M.; Prough, Donald.
In: Best Practice and Research: Clinical Anaesthesiology, Vol. 23, No. 2, 06.2009, p. 213-224.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic aspects of fluid therapy
AU - Svensen, Christer H.
AU - Rodhe, Peter M.
AU - Prough, Donald
PY - 2009/6
Y1 - 2009/6
N2 - Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.
AB - Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.
KW - anaesthesia
KW - anaesthetics
KW - biological
KW - blood pressure
KW - body weight
KW - cardiac output
KW - colouring agents
KW - fluid therapy
KW - haemoglobins
KW - heart rate
KW - humans
KW - indocyanine green
KW - inhalation
KW - isoflurane
KW - models
KW - population
KW - sodium chloride
UR - http://www.scopus.com/inward/record.url?scp=66749094044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66749094044&partnerID=8YFLogxK
U2 - 10.1016/j.bpa.2008.11.003
DO - 10.1016/j.bpa.2008.11.003
M3 - Article
VL - 23
SP - 213
EP - 224
JO - Bailliere's Best Practice and Research in Clinical Anaesthesiology
JF - Bailliere's Best Practice and Research in Clinical Anaesthesiology
SN - 1521-6896
IS - 2
ER -