Pharmacokinetic aspects of fluid therapy

Christer H. Svensen, Peter M. Rodhe, Donald Prough

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.

Original languageEnglish (US)
Pages (from-to)213-224
Number of pages12
JournalBest Practice and Research: Clinical Anaesthesiology
Volume23
Issue number2
DOIs
StatePublished - Jun 2009

Fingerprint

Fluid Therapy
Pharmacokinetics
Empiricism
Pharmaceutical Preparations

Keywords

  • anaesthesia
  • anaesthetics
  • biological
  • blood pressure
  • body weight
  • cardiac output
  • colouring agents
  • fluid therapy
  • haemoglobins
  • heart rate
  • humans
  • indocyanine green
  • inhalation
  • isoflurane
  • models
  • population
  • sodium chloride

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Pharmacokinetic aspects of fluid therapy. / Svensen, Christer H.; Rodhe, Peter M.; Prough, Donald.

In: Best Practice and Research: Clinical Anaesthesiology, Vol. 23, No. 2, 06.2009, p. 213-224.

Research output: Contribution to journalArticle

Svensen, Christer H. ; Rodhe, Peter M. ; Prough, Donald. / Pharmacokinetic aspects of fluid therapy. In: Best Practice and Research: Clinical Anaesthesiology. 2009 ; Vol. 23, No. 2. pp. 213-224.
@article{26cc75fb684c4b719e0008a79d34e340,
title = "Pharmacokinetic aspects of fluid therapy",
abstract = "Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.",
keywords = "anaesthesia, anaesthetics, biological, blood pressure, body weight, cardiac output, colouring agents, fluid therapy, haemoglobins, heart rate, humans, indocyanine green, inhalation, isoflurane, models, population, sodium chloride",
author = "Svensen, {Christer H.} and Rodhe, {Peter M.} and Donald Prough",
year = "2009",
month = "6",
doi = "10.1016/j.bpa.2008.11.003",
language = "English (US)",
volume = "23",
pages = "213--224",
journal = "Bailliere's Best Practice and Research in Clinical Anaesthesiology",
issn = "1521-6896",
publisher = "Bailliere Tindall Ltd",
number = "2",

}

TY - JOUR

T1 - Pharmacokinetic aspects of fluid therapy

AU - Svensen, Christer H.

AU - Rodhe, Peter M.

AU - Prough, Donald

PY - 2009/6

Y1 - 2009/6

N2 - Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.

AB - Peri-operative fluid therapy continues to be an exercise in empiricism, with nagging questions about efficacy and complications. Pharmacokinetics is used for studying the time dependency of administered drugs. Volume kinetics is a pharmacokinetic approach describing the peak effects and clearance of intravenously infused fluids. It clarifies the absorption, distribution, metabolism and excretion of an intravenous fluid bolus. This could possibly allow for more rational design of intravenous fluid paradigms to improve clinical fluid therapy. This chapter briefly summarizes currently accepted principles of fluid therapy, discusses the general approach to kinetic analysis of fluid therapy, reviews currently available data defining kinetic responses to fluid therapy, and speculates about future applications of this approach.

KW - anaesthesia

KW - anaesthetics

KW - biological

KW - blood pressure

KW - body weight

KW - cardiac output

KW - colouring agents

KW - fluid therapy

KW - haemoglobins

KW - heart rate

KW - humans

KW - indocyanine green

KW - inhalation

KW - isoflurane

KW - models

KW - population

KW - sodium chloride

UR - http://www.scopus.com/inward/record.url?scp=66749094044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66749094044&partnerID=8YFLogxK

U2 - 10.1016/j.bpa.2008.11.003

DO - 10.1016/j.bpa.2008.11.003

M3 - Article

VL - 23

SP - 213

EP - 224

JO - Bailliere's Best Practice and Research in Clinical Anaesthesiology

JF - Bailliere's Best Practice and Research in Clinical Anaesthesiology

SN - 1521-6896

IS - 2

ER -