Pharmacokinetics and drug resistance of melphalan in regional chemotherapy: ILP versus ILI

James C. Padussis, Samuel N. Steerman, Douglas Tyler, Paul J. Mosca

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Two forms of regional chemotherapy for the treatment of advanced melanoma or sarcoma of the extremity are isolated limb perfusion (ILP) and the more recently described isolated limb infusion (ILI). Melphalan is the most commonly employed agent in both ILP and ILI, although it is often used in conjunction with other cytotoxic and/or biologic therapies. While ILP and ILI are far more effective for the treatment of extremity disease than is systemic therapy, there is still significant room for improvement in outcomes, from the standpoint of both response rate and toxicity. An understanding of the pharmacokinetics of regional chemotherapy would allow for the prediction of tumor response and toxicity and therefore patient outcomes. In addition, elucidating the mechanisms of drug resistance would lead to opportunities to develop effective chemo-modulators that enhance the effectiveness of ILP and ILI. This paper reviews progress in these two key areas of active investigation.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalInternational Journal of Hyperthermia
Volume24
Issue number3
DOIs
StatePublished - May 2008
Externally publishedYes

Fingerprint

Melphalan
Drug Resistance
Extremities
Pharmacokinetics
Perfusion
Drug Therapy
Biological Therapy
Sarcoma
Melanoma
Therapeutics

Keywords

  • Chemo-modulator
  • Glutathione
  • Isolated limb infusion
  • Isolated limb perfusion
  • Two-compartment model

ASJC Scopus subject areas

  • Cancer Research
  • Radiological and Ultrasound Technology

Cite this

Pharmacokinetics and drug resistance of melphalan in regional chemotherapy : ILP versus ILI. / Padussis, James C.; Steerman, Samuel N.; Tyler, Douglas; Mosca, Paul J.

In: International Journal of Hyperthermia, Vol. 24, No. 3, 05.2008, p. 239-249.

Research output: Contribution to journalArticle

Padussis, James C. ; Steerman, Samuel N. ; Tyler, Douglas ; Mosca, Paul J. / Pharmacokinetics and drug resistance of melphalan in regional chemotherapy : ILP versus ILI. In: International Journal of Hyperthermia. 2008 ; Vol. 24, No. 3. pp. 239-249.
@article{28864a0fdedc43998b5da990b425f3aa,
title = "Pharmacokinetics and drug resistance of melphalan in regional chemotherapy: ILP versus ILI",
abstract = "Two forms of regional chemotherapy for the treatment of advanced melanoma or sarcoma of the extremity are isolated limb perfusion (ILP) and the more recently described isolated limb infusion (ILI). Melphalan is the most commonly employed agent in both ILP and ILI, although it is often used in conjunction with other cytotoxic and/or biologic therapies. While ILP and ILI are far more effective for the treatment of extremity disease than is systemic therapy, there is still significant room for improvement in outcomes, from the standpoint of both response rate and toxicity. An understanding of the pharmacokinetics of regional chemotherapy would allow for the prediction of tumor response and toxicity and therefore patient outcomes. In addition, elucidating the mechanisms of drug resistance would lead to opportunities to develop effective chemo-modulators that enhance the effectiveness of ILP and ILI. This paper reviews progress in these two key areas of active investigation.",
keywords = "Chemo-modulator, Glutathione, Isolated limb infusion, Isolated limb perfusion, Two-compartment model",
author = "Padussis, {James C.} and Steerman, {Samuel N.} and Douglas Tyler and Mosca, {Paul J.}",
year = "2008",
month = "5",
doi = "10.1080/02656730701816410",
language = "English (US)",
volume = "24",
pages = "239--249",
journal = "International Journal of Hyperthermia",
issn = "0265-6736",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Pharmacokinetics and drug resistance of melphalan in regional chemotherapy

T2 - ILP versus ILI

AU - Padussis, James C.

AU - Steerman, Samuel N.

AU - Tyler, Douglas

AU - Mosca, Paul J.

PY - 2008/5

Y1 - 2008/5

N2 - Two forms of regional chemotherapy for the treatment of advanced melanoma or sarcoma of the extremity are isolated limb perfusion (ILP) and the more recently described isolated limb infusion (ILI). Melphalan is the most commonly employed agent in both ILP and ILI, although it is often used in conjunction with other cytotoxic and/or biologic therapies. While ILP and ILI are far more effective for the treatment of extremity disease than is systemic therapy, there is still significant room for improvement in outcomes, from the standpoint of both response rate and toxicity. An understanding of the pharmacokinetics of regional chemotherapy would allow for the prediction of tumor response and toxicity and therefore patient outcomes. In addition, elucidating the mechanisms of drug resistance would lead to opportunities to develop effective chemo-modulators that enhance the effectiveness of ILP and ILI. This paper reviews progress in these two key areas of active investigation.

AB - Two forms of regional chemotherapy for the treatment of advanced melanoma or sarcoma of the extremity are isolated limb perfusion (ILP) and the more recently described isolated limb infusion (ILI). Melphalan is the most commonly employed agent in both ILP and ILI, although it is often used in conjunction with other cytotoxic and/or biologic therapies. While ILP and ILI are far more effective for the treatment of extremity disease than is systemic therapy, there is still significant room for improvement in outcomes, from the standpoint of both response rate and toxicity. An understanding of the pharmacokinetics of regional chemotherapy would allow for the prediction of tumor response and toxicity and therefore patient outcomes. In addition, elucidating the mechanisms of drug resistance would lead to opportunities to develop effective chemo-modulators that enhance the effectiveness of ILP and ILI. This paper reviews progress in these two key areas of active investigation.

KW - Chemo-modulator

KW - Glutathione

KW - Isolated limb infusion

KW - Isolated limb perfusion

KW - Two-compartment model

UR - http://www.scopus.com/inward/record.url?scp=42049119491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42049119491&partnerID=8YFLogxK

U2 - 10.1080/02656730701816410

DO - 10.1080/02656730701816410

M3 - Article

C2 - 18393002

AN - SCOPUS:42049119491

VL - 24

SP - 239

EP - 249

JO - International Journal of Hyperthermia

JF - International Journal of Hyperthermia

SN - 0265-6736

IS - 3

ER -