Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model

John A. Moss, Amanda M. Malone, Thomas J. Smith, Sean Kennedy, Cali Nguyen, Kathleen L. Vincent, Massoud Motamedi, Marc M. Baum

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

Original languageEnglish (US)
Pages (from-to)3994-3997
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume57
Issue number8
DOIs
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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