Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model

John A. Moss; Amanda M. Malone; Thomas J. Smith; Sean Kennedy; Cali Nguyen; Kathleen L. Vincent; Massoud Motamedi; Marc M. Baum

doi:10.1128/AAC.00547-13

Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model

John A. Moss, Amanda M. Malone, Thomas J. Smith, Sean Kennedy, Cali Nguyen, Kathleen L. Vincent, Massoud Motamedi, Marc M. Baum

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

Original language	English (US)
Pages (from-to)	3994-3997
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	57
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00547-13
State	Published - Aug 2013

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.",

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AU - Moss, John A.

AU - Malone, Amanda M.

AU - Smith, Thomas J.

AU - Kennedy, Sean

AU - Nguyen, Cali

AU - Vincent, Kathleen L.

AU - Motamedi, Massoud

AU - Baum, Marc M.

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AB - Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

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Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model

Abstract

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