Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform

Keyphrases

• Inducible Nitric Oxide Synthase 100%
• Nitric Oxide Synthase Inhibitors 100%
• Novel Inhibitors 100%
• Pharmacological Characterization 100%
• NO Synthase 33%
• Endotoxin Shock 33%
• Enzyme Level 25%
• Inhibitory Effect 16%
• Cultured Cells 16%
• Nitric Oxide 16%
• Vascular Ring 16%
• Bacterial Lipopolysaccharide 16%
• Bolus 16%
• Arginine 16%
• Endothelium-dependent Relaxation 16%
• Blood Pressure 8%
• Vascular Reactivity 8%
• Inflammatory Cytokines 8%
• Survival Rate 8%
• Acetylcholine 8%
• Lipopolysaccharide 8%
• Beneficial Effects 8%
• Rat Model 8%
• Experimental Therapeutics 8%
• 4-fold 8%
• Thoracic Aorta 8%
• IC50 Value 8%
• Lung Epithelial Cells 8%
• Non-competitive 8%
• Mean Arterial Pressure 8%
• Dimerization 8%
• Tetrahydrobiopterin 8%
• In Vivo Applications 8%
• Inflammatory Conditions 8%
• Guanidine 8%
• Mercaptoethylguanidine 8%
• Endothelial Nitric Oxide Synthase (eNOS) 8%
• Noradrenaline 8%
• Species-dependent 8%
• Endotoxemia 8%
• Competitive Inhibitor 8%
• EC50 8%
• Endothelium-dependent 8%
• Human Aortic Smooth muscle Cells (HASMCs) 8%
• Overproduction 8%
• Pharmacological Properties 8%
• Cell Uptake 8%
• Vascular Hyporeactivity 8%
• Immunostimulation 8%
• Amidines 8%
• DLD-1 Cells 8%
• Methylene Blue 8%
• Murine Lung 8%
• NOS Activity 8%
• Soluble Guanylyl Cyclase 8%
• J774 Macrophages 8%
• Nitrite Formation 8%
• Inhibitory Potency 8%
• Vascular Studies 8%
• Nitrite Production 8%
• NOS Expression 8%
• Uptake by Cells 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Nitric Oxide Synthase 100%
• Septic Shock 44%
• Nitric Oxide 22%
• Vascular Ring 22%
• Bacterium Lipopolysaccharide 22%
• Nitrite 22%
• Arginine 22%
• EC50 22%
• Inflammation 11%
• Cytokine 11%
• Lipopolysaccharide 11%
• Rat Model 11%
• Survival Rate 11%
• Acetylcholine 11%
• Noradrenalin 11%
• Guanidine Derivative 11%
• Endotoxemia 11%
• Competitive Inhibitor 11%
• Guanylate Cyclase 11%
• Amidinium 11%
• Sapropterin 11%
• Carbene 11%