Pharmacologically targeting the fibroblast growth factor 14 interaction site on the voltage-gated na⁺ channel 1.6 enables isoform-selective modulation

Keyphrases

• Nav Channels 100%
• Fn14 100%
• Isoform Selectivity 100%
• Voltage-gated Channels 100%
• Interaction Sites 100%
• Selective Modulation 100%
• NaV1.6 Channels 40%
• Protein-protein Interaction 30%
• Central Nervous System 30%
• Auxiliary Proteins 30%
• Nucleus Accumbens 20%
• Action Potential 20%
• Medium Spiny Neurons 20%
• Na + 20%
• Channel Subunits 20%
• Targeted Therapeutics 10%
• Amino Acid Sequence 10%
• Differential Expression 10%
• Dose Effect 10%
• Brain Regions 10%
• Neuronal Cells 10%
• Subcellular Distribution 10%
• Molecular Determinants 10%
• Mesocorticolimbic Circuit 10%
• Voltage Gating 10%
• Neuromodulators 10%
• Current Therapeutics 10%
• Nav1.2 10%
• Nav1.2 Channel 10%
• Nav1.6 10%
• Promising Target 10%
• Sequence Divergence 10%
• Peptidomimetics 10%
• Nav1.1 10%
• Nav1.1 Channel 10%
• Neuromodulation 10%
• Electrical Output 10%

Neuroscience

• Fibroblast Growth Factor 14 100%
• Sodium Channel 100%
• C-Terminus 100%
• Sodium Channel Nav1.6 100%
• Central Nervous System 75%
• Nucleus Accumbens 50%
• Action Potential 50%
• Medium Spiny Neuron 50%
• Amino Acid Sequence 25%
• Sodium Channel Nav1.2 25%
• Nav1.2 25%
• Sodium Channel Nav1.1 25%
• Nav1.1 25%
• Neuromodulation 25%
• Side Effect 25%
• Brain Region 25%

Biochemistry, Genetics and Molecular Biology

• Isoform 100%
• Electric Potential 100%
• Fibroblast Growth Factor 100%
• Sodium Channel 100%
• C-Terminus 50%
• Action Potential 25%
• Nav1.2 25%
• Nav1.1 25%
• Medium Spiny Neuron 25%
• Subcellular Localization 12%
• Peptide Sequence 12%
• Peptidomimetic 12%
• Differential Display 12%
• Neuromodulation 12%