Pharmacology of antiviral chemotherapeutic agents useful in human viral infections of the nervous system

R. R. McKendall

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several drugs that have antiviral activity and acceptably low toxicity for systemic use in humans have been discussed in this paper. For ara-A, acycloguanosine, and interferon, there is convincing evidence of effectiveness in limiting certain viral diseases of the nervous system. At this moment use of these drugs cannot be justified for benign, self-limiting, and uncomplicated viral diseases (e.g., localized herpes labialis). However, data from large controlled clinical trials are just beginning to be available and therefore the indications for use of these drugs may change rapidly. It is anticipated that these drugs will have a definite and welcome role in medical therapeutics.

Original languageEnglish (US)
Pages (from-to)115-129
Number of pages15
JournalClinical Neuropharmacology
Volume5
Issue number1
StatePublished - 1982

Fingerprint

Virus Diseases
Nervous System
Antiviral Agents
Pharmacology
Herpes Labialis
Pharmaceutical Preparations
Vidarabine
Acyclovir
Controlled Clinical Trials
Interferons
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pharmacology of antiviral chemotherapeutic agents useful in human viral infections of the nervous system. / McKendall, R. R.

In: Clinical Neuropharmacology, Vol. 5, No. 1, 1982, p. 115-129.

Research output: Contribution to journalArticle

@article{f529033663e648b9b38047715887bb2d,
title = "Pharmacology of antiviral chemotherapeutic agents useful in human viral infections of the nervous system",
abstract = "Several drugs that have antiviral activity and acceptably low toxicity for systemic use in humans have been discussed in this paper. For ara-A, acycloguanosine, and interferon, there is convincing evidence of effectiveness in limiting certain viral diseases of the nervous system. At this moment use of these drugs cannot be justified for benign, self-limiting, and uncomplicated viral diseases (e.g., localized herpes labialis). However, data from large controlled clinical trials are just beginning to be available and therefore the indications for use of these drugs may change rapidly. It is anticipated that these drugs will have a definite and welcome role in medical therapeutics.",
author = "McKendall, {R. R.}",
year = "1982",
language = "English (US)",
volume = "5",
pages = "115--129",
journal = "Clinical Neuropharmacology",
issn = "0362-5664",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Pharmacology of antiviral chemotherapeutic agents useful in human viral infections of the nervous system

AU - McKendall, R. R.

PY - 1982

Y1 - 1982

N2 - Several drugs that have antiviral activity and acceptably low toxicity for systemic use in humans have been discussed in this paper. For ara-A, acycloguanosine, and interferon, there is convincing evidence of effectiveness in limiting certain viral diseases of the nervous system. At this moment use of these drugs cannot be justified for benign, self-limiting, and uncomplicated viral diseases (e.g., localized herpes labialis). However, data from large controlled clinical trials are just beginning to be available and therefore the indications for use of these drugs may change rapidly. It is anticipated that these drugs will have a definite and welcome role in medical therapeutics.

AB - Several drugs that have antiviral activity and acceptably low toxicity for systemic use in humans have been discussed in this paper. For ara-A, acycloguanosine, and interferon, there is convincing evidence of effectiveness in limiting certain viral diseases of the nervous system. At this moment use of these drugs cannot be justified for benign, self-limiting, and uncomplicated viral diseases (e.g., localized herpes labialis). However, data from large controlled clinical trials are just beginning to be available and therefore the indications for use of these drugs may change rapidly. It is anticipated that these drugs will have a definite and welcome role in medical therapeutics.

UR - http://www.scopus.com/inward/record.url?scp=0020323216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020323216&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 115

EP - 129

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

SN - 0362-5664

IS - 1

ER -