Pharmasat: Drug dose dependence results from an autonomous microsystem-based small satellite in low earth orbit

A. J. Ricco, M. Parra, M. Piccini, D. Ly, D. Niesel, M. McGinnis, A. Kudlicki, J. W. Hines, L. Timucin, C. Beasley, R. Ricks, M. McIntyre, C. Friedericks, M. Henschke, R. Leung, M. Diaz-Aguado, C. Kitts, I. Mas, R. Rasay, E. AgasidE. Luzzi, K. Ronzano, D. Squires, B. Yost

Research output: Chapter in Book/Report/Conference proceedingConference contribution

12 Scopus citations

Abstract

We designed, built, tested, space-qualified, launched, and downlinked bioanalytical data from PharmaSat, the first fully autonomous outer-space pharmaceutical dose-response bioanalytical system on a free-flying satellite. PharmaSat tracks microorganism culture population density and metabolic activity in 48 microw-ells via 3-color optical absorbance. Its 5.1-kg total mass includes solar cells, integrated spacecraft “bus” module (power/batteries/ control/communications), and a sealed containment vessel housing the biofluidic, optical, thermal, and sensor subsystems. Data were obtained from all subsystems over several days following nutrient introduction to initiate growth of Saccharomyces cerevisiae, followed by challenges with three dose levels of an antifungal agent.

Original languageEnglish (US)
Title of host publication2010 Solid-State Sensors, Actuators, and Microsystems Workshop
EditorsDavid J. Monk, Kimberly L. Turner
PublisherTransducer Research Foundation
Pages110-113
Number of pages4
ISBN (Electronic)0964002485, 9780964002487
DOIs
StatePublished - 2010
Externally publishedYes
Event2010 Solid-State Sensors, Actuators, and Microsystems Workshop - Hilton Head Island, United States
Duration: Jun 6 2010Jun 10 2010

Publication series

NameTechnical Digest - Solid-State Sensors, Actuators, and Microsystems Workshop

Conference

Conference2010 Solid-State Sensors, Actuators, and Microsystems Workshop
Country/TerritoryUnited States
CityHilton Head Island
Period6/6/106/10/10

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering
  • Hardware and Architecture

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