PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite

Antonio J. Ricco; MacArena Parra; David Niesel; Matthew Piccini; Diana Ly; Michael McGinnis; Andrzej Kudlicki; John W. Hines; Linda Timucin; Chris Beasley; Robert Ricks; Michael McIntyre; Charlie Friedericks; Michael Henschke; Ricky Leung; Millan Diaz-Aguado; Christopher Kitts; Ignacio Mas; Mike Rasay; Elwood Agasid; Ed Luzzi; Karolyn Ronzano; David Squires; Bruce Yost

doi:10.1117/12.881082

PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite

Antonio J. Ricco, MacArena Parra, David Niesel, Matthew Piccini, Diana Ly, Michael McGinnis, Andrzej Kudlicki, John W. Hines, Linda Timucin, Chris Beasley, Robert Ricks, Michael McIntyre, Charlie Friedericks, Michael Henschke, Ricky Leung, Millan Diaz-Aguado, Christopher Kitts, Ignacio Mas, Mike Rasay, Elwood AgasidEd Luzzi, Karolyn Ronzano, David Squires, Bruce Yost

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

27 Scopus citations

Abstract

We designed, built, tested, space-qualified, launched, and collected telemetered data from low Earth orbit from Pharma- Sat, a 5.1-kg free flying "nanosatellite" that supported microbial growth in 48 microfluidic wells, dosed microbes with multiple concentrations of a pharmaceutical agent, and monitored microbial growth and metabolic activity using a dedicated 3-color optical absorbance system at each microwell. The PharmaSat nanosatellite comprised a structure approximately 10 x 10 x 35 cm, including triple-junction solar cells, bidirectional communications, power-generation and energy- storage system, and a sealed payload 1.2-L containment vessel that housed the biological organisms along with the fluidic, optical, thermal, sensor, and electronic subsystems. Growth curves for S. cerevisiae (Brewer's yeast) were obtained for multiple concentrations of the antifungal drug voriconazole in the microgravity conditions of low Earth orbit. Corresponding terrestrial control experiments were conducted for comparison.

Original language	English (US)
Title of host publication	Microfluidics, BioMEMS, and Medical Microsystems IX
DOIs	https://doi.org/10.1117/12.881082
State	Published - 2011
Event	Microfluidics, BioMEMS, and Medical Microsystems IX - San Francisco, CA, United States Duration: Jan 23 2011 → Jan 25 2011

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	7929
ISSN (Print)	0277-786X

Other

Other	Microfluidics, BioMEMS, and Medical Microsystems IX
Country/Territory	United States
City	San Francisco, CA
Period	1/23/11 → 1/25/11

Keywords

PharmaSat
integrated microsystem
microfluidics
nanosatellite
optical absorbance
voriconazole
yeast

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.881082

Cite this

Ricco, A. J., Parra, M., Niesel, D., Piccini, M., Ly, D., McGinnis, M., Kudlicki, A., Hines, J. W., Timucin, L., Beasley, C., Ricks, R., McIntyre, M., Friedericks, C., Henschke, M., Leung, R., Diaz-Aguado, M., Kitts, C., Mas, I., Rasay, M., ... Yost, B. (2011). PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite. In Microfluidics, BioMEMS, and Medical Microsystems IX Article 79290T (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7929). https://doi.org/10.1117/12.881082

PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite. / Ricco, Antonio J.; Parra, MacArena; Niesel, David et al.
Microfluidics, BioMEMS, and Medical Microsystems IX. 2011. 79290T (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7929).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ricco, AJ, Parra, M, Niesel, D, Piccini, M, Ly, D, McGinnis, M, Kudlicki, A, Hines, JW, Timucin, L, Beasley, C, Ricks, R, McIntyre, M, Friedericks, C, Henschke, M, Leung, R, Diaz-Aguado, M, Kitts, C, Mas, I, Rasay, M, Agasid, E, Luzzi, E, Ronzano, K, Squires, D & Yost, B 2011, PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite. in Microfluidics, BioMEMS, and Medical Microsystems IX., 79290T, Proceedings of SPIE - The International Society for Optical Engineering, vol. 7929, Microfluidics, BioMEMS, and Medical Microsystems IX, San Francisco, CA, United States, 1/23/11. https://doi.org/10.1117/12.881082

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AB - We designed, built, tested, space-qualified, launched, and collected telemetered data from low Earth orbit from Pharma- Sat, a 5.1-kg free flying "nanosatellite" that supported microbial growth in 48 microfluidic wells, dosed microbes with multiple concentrations of a pharmaceutical agent, and monitored microbial growth and metabolic activity using a dedicated 3-color optical absorbance system at each microwell. The PharmaSat nanosatellite comprised a structure approximately 10 x 10 x 35 cm, including triple-junction solar cells, bidirectional communications, power-generation and energy- storage system, and a sealed payload 1.2-L containment vessel that housed the biological organisms along with the fluidic, optical, thermal, sensor, and electronic subsystems. Growth curves for S. cerevisiae (Brewer's yeast) were obtained for multiple concentrations of the antifungal drug voriconazole in the microgravity conditions of low Earth orbit. Corresponding terrestrial control experiments were conducted for comparison.

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PharmaSat: Drug dose response in microgravity from a free-flying integrated biofluidic/optical culture-and-analysis satellite

Abstract

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Keywords

ASJC Scopus subject areas

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