Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity

K. M. Johnson; T. W. Vickroy

Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity

K. M. Johnson, T. W. Vickroy

Pharmacology & Toxicology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.

Original language	English (US)
Pages (from-to)	73-76
Number of pages	4
Journal	Psychopharmacology bulletin
Volume	16
Issue number	4
State	Published - Dec 1 1980

ASJC Scopus subject areas

Psychiatry and Mental health
Pharmacology (medical)

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title = "Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity",

abstract = "Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.",

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N2 - Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.

AB - Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.

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