Abstract
Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Psychopharmacology Bulletin |
| Volume | 16 |
| Issue number | 4 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology
Cite this
Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity. / Johnson, K. M.; Vickroy, T. W.
In: Psychopharmacology Bulletin, Vol. 16, No. 4, 1980, p. 73-76.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity
AU - Johnson, K. M.
AU - Vickroy, T. W.
PY - 1980
Y1 - 1980
N2 - Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.
AB - Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019220144&partnerID=8YFLogxK
M3 - Article
C2 - 6109354
AN - SCOPUS:0019220144
VL - 16
SP - 73
EP - 76
JO - Psychopharmacology Bulletin
JF - Psychopharmacology Bulletin
SN - 0048-5764
IS - 4
ER -