Phencyclidine-induced stimulation of synaptosomal tyrosine hydroxylase activity

K. M. Johnson, T. W. Vickroy

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Since tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis, is involved in the regulation of dopaminergic function in the rat, the authors studied the effects of PCP on tyrosine hydroxylase activity. The results suggest that PCP stimulates the activity of tyrosine hydroxylase by releasing DA from a reserpine-sensitive site, and under the described conditions this pool (probably vesicular) normally contributes to the tonic inhibition of this enzyme.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalPsychopharmacology bulletin
Issue number4
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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