Abstract
Aim: The aim of this article is to present a case of a phenobarbital- induced gingival hyperplasia (GH), discuss possible etiological mechanisms of drug-induced GH, and to present a concise review of the literature. Background: GH is a well-known complication associated with anticonvulsant phenytoin, antihypertensive calcium channel blockers, and immunosuppressant cyclosporine therapy. Sodium valproate and primidone has very rarely been found to cause GH. Report: An extremely rare case of phenobarbital-induced GH in a 28-year-old male patient who had received this drug for three years is presented. The histological examination of the lesion revealed a hyperplastic epithelium, epithelial acanthosis, and elongated rete ridges as well as obviously enhanced dense collagenous fibers and proliferation of fibroblasts. Summary: Phenobarbital-induced GH is a rare clinical entity which necessitates meticulous evaluation. However, it seems to show a benign behavior with reference to recurrence after surgical excision.
Original language | English (US) |
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Pages (from-to) | 50-56 |
Number of pages | 7 |
Journal | Journal of Contemporary Dental Practice |
Volume | 8 |
Issue number | 6 |
DOIs | |
State | Published - Jan 9 2007 |
Externally published | Yes |
Keywords
- Hyperplasia
- Phenobarbital
- Pseudoepitheliomatous hyperplasia
ASJC Scopus subject areas
- General Dentistry