Phenobarbital-induced gingival hyperplasia

Ardeshir Lafzi, Ramin Mostofi Zadeh Farahani, Mohammadali Mohajel Shoja

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aim: The aim of this article is to present a case of a phenobarbital- induced gingival hyperplasia (GH), discuss possible etiological mechanisms of drug-induced GH, and to present a concise review of the literature. Background: GH is a well-known complication associated with anticonvulsant phenytoin, antihypertensive calcium channel blockers, and immunosuppressant cyclosporine therapy. Sodium valproate and primidone has very rarely been found to cause GH. Report: An extremely rare case of phenobarbital-induced GH in a 28-year-old male patient who had received this drug for three years is presented. The histological examination of the lesion revealed a hyperplastic epithelium, epithelial acanthosis, and elongated rete ridges as well as obviously enhanced dense collagenous fibers and proliferation of fibroblasts. Summary: Phenobarbital-induced GH is a rare clinical entity which necessitates meticulous evaluation. However, it seems to show a benign behavior with reference to recurrence after surgical excision.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalJournal of Contemporary Dental Practice
Volume8
Issue number6
StatePublished - Jan 9 2007
Externally publishedYes

Fingerprint

Gingival Hyperplasia
Phenobarbital
Primidone
Calcium Channel Blockers
Valproic Acid
Phenytoin
Immunosuppressive Agents
Pharmaceutical Preparations
Anticonvulsants
Antihypertensive Agents
Cyclosporine
Epithelium
Fibroblasts
Recurrence

Keywords

  • Hyperplasia
  • Phenobarbital
  • Pseudoepitheliomatous hyperplasia

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Lafzi, A., Farahani, R. M. Z., & Mohajel Shoja, M. (2007). Phenobarbital-induced gingival hyperplasia. Journal of Contemporary Dental Practice, 8(6), 50-56.

Phenobarbital-induced gingival hyperplasia. / Lafzi, Ardeshir; Farahani, Ramin Mostofi Zadeh; Mohajel Shoja, Mohammadali.

In: Journal of Contemporary Dental Practice, Vol. 8, No. 6, 09.01.2007, p. 50-56.

Research output: Contribution to journalArticle

Lafzi, A, Farahani, RMZ & Mohajel Shoja, M 2007, 'Phenobarbital-induced gingival hyperplasia', Journal of Contemporary Dental Practice, vol. 8, no. 6, pp. 50-56.
Lafzi A, Farahani RMZ, Mohajel Shoja M. Phenobarbital-induced gingival hyperplasia. Journal of Contemporary Dental Practice. 2007 Jan 9;8(6):50-56.
Lafzi, Ardeshir ; Farahani, Ramin Mostofi Zadeh ; Mohajel Shoja, Mohammadali. / Phenobarbital-induced gingival hyperplasia. In: Journal of Contemporary Dental Practice. 2007 ; Vol. 8, No. 6. pp. 50-56.
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