Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria

Kimberlee Michals, Mary Lopus, Reuben Matalon

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.

Original languageEnglish (US)
Pages (from-to)18-23
Number of pages6
JournalBiochemical Medicine and Metabolic Biology
Volume39
Issue number1
DOIs
StatePublished - Feb 1988
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry

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