Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria

Kimberlee Michals; Mary Lopus; Reuben Matalon

doi:10.1016/0885-4505(88)90053-9

Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria

Kimberlee Michals, Mary Lopus, Reuben Matalon

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.

Original language	English (US)
Pages (from-to)	18-23
Number of pages	6
Journal	Biochemical Medicine and Metabolic Biology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/0885-4505(88)90053-9
State	Published - Feb 1988
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry

Access to Document

10.1016/0885-4505(88)90053-9

Cite this

@article{ffe20ecd11a64f74af5b89417c865d55,

title = "Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria",

abstract = "The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.",

author = "Kimberlee Michals and Mary Lopus and Reuben Matalon",

year = "1988",

month = feb,

doi = "10.1016/0885-4505(88)90053-9",

language = "English (US)",

volume = "39",

pages = "18--23",

journal = "Biochemical Medicine and Metabolic Biology",

issn = "0885-4505",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria

AU - Michals, Kimberlee

AU - Lopus, Mary

AU - Matalon, Reuben

PY - 1988/2

Y1 - 1988/2

N2 - The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.

AB - The data from this study showed that the excretion of three major metabolites of phenylalanine in patients with PKU approach normal values at blood phenylalanine levels less than 5.0 mg/dl. The MANOVA showed statistically significant differences in phenyllactate excretion when blood phenylalanine was greater than 10.0 mg/dl. The PL and total metabolite excretion were significantly correlated to blood phenylalanine in multiple samples taken from two individual subjects. Using data obtained from single patient observations may serve as a means for individualizing the PKU diet to insure low levels of phenylalanine metabolites and thus insure optimal development for patients with PKU.

UR - http://www.scopus.com/inward/record.url?scp=0023854430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023854430&partnerID=8YFLogxK

U2 - 10.1016/0885-4505(88)90053-9

DO - 10.1016/0885-4505(88)90053-9

M3 - Article

C2 - 3355711

AN - SCOPUS:0023854430

SN - 0885-4505

VL - 39

SP - 18

EP - 23

JO - Biochemical Medicine and Metabolic Biology

JF - Biochemical Medicine and Metabolic Biology

IS - 1

ER -

Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this