Phenylalanine metabolites, attention span and hyperactivity.

K. Michals, Reuben Matalon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The metabolites of phenylalanine, phenylacetate, phenyllactate, phenylpyruvate and phenylethylamine, were measured in the urine of PKU patients. In general correlation was found between serum phenylalanine excretion of these metabolites. However, there were individual variations in the quantities and type of metabolites excreted that could not be explained by blood phenylalanine levels. In a PKU pregnancy large quantities of phenylalanine metabolites were found in urine despite a modest elevation of serum phenylalanine. Increase in the excretion of phenylalanine metabolites was found in patients who were considered to have good blood phenylalanine control. These preliminary studies indicate that the current practice of allowing a wide range of blood phenylalanine in the treatment of PKU may have to be reexamined. Since these metabolites are neurotoxic, they may afford a new parameter for the study of PKU not only regarding the prevention of mental retardation but also with regards to behavior and learning disabilities.

Original languageEnglish (US)
Pages (from-to)361-365
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume42
Issue number2
StatePublished - Aug 1985
Externally publishedYes

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Phenylalanine
phenylalanine
metabolites
blood serum
blood
urine
excretion
Urine
phenylacetic acid
Phenethylamines
phenethylamines
Learning Disorders
Serum
Intellectual Disability
learning
pregnancy
Pregnancy

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Phenylalanine metabolites, attention span and hyperactivity. / Michals, K.; Matalon, Reuben.

In: American Journal of Clinical Nutrition, Vol. 42, No. 2, 08.1985, p. 361-365.

Research output: Contribution to journalArticle

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