Phenytoin liver glutathione depletion. A possible mechanism of liver injury

W. R. Snodgrass, S. Whitfield

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Phenytoin produces significant liver glutathione depletion in vivo in mice. Pretreatment with inducers and inhibitors of drug metabolism show enhancement of phenytoin-induced glutathione depletion following phenobarbital and 3-methylcholanthrene pretreatment, inhibition of glutathione depletion following piperonyl butoxide, cobaltous chloride and alpha-naphthylisothiocyanate pretreatment (all drug metabolism inhibitors), and prevention of glutathione depletion following butylated hydroxytoluene pretreatment (both inducers of epoxide hydrolase). These data suggest that phenytoin-induced liver glutathione depletion may occur via a reactive metabolite and that this reactive metabolite possibly may be an epoxide.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalVeterinary and Human Toxicology
Volume23
Issue numberSuppl. 1
StatePublished - 1981
Externally publishedYes

Fingerprint

phenytoin
Phenytoin
Liver
Glutathione
glutathione
pretreatment
liver
Wounds and Injuries
Metabolites
Metabolism
pharmacokinetics
1-Naphthylisothiocyanate
Piperonyl Butoxide
epoxide hydrolase
metabolites
Epoxide Hydrolases
Butylated Hydroxytoluene
phenobarbital
piperonyl butoxide
Methylcholanthrene

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology
  • veterinary(all)

Cite this

Phenytoin liver glutathione depletion. A possible mechanism of liver injury. / Snodgrass, W. R.; Whitfield, S.

In: Veterinary and Human Toxicology, Vol. 23, No. Suppl. 1, 1981, p. 5-7.

Research output: Contribution to journalArticle

Snodgrass, WR & Whitfield, S 1981, 'Phenytoin liver glutathione depletion. A possible mechanism of liver injury', Veterinary and Human Toxicology, vol. 23, no. Suppl. 1, pp. 5-7.
Snodgrass, W. R. ; Whitfield, S. / Phenytoin liver glutathione depletion. A possible mechanism of liver injury. In: Veterinary and Human Toxicology. 1981 ; Vol. 23, No. Suppl. 1. pp. 5-7.
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