PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Sergio Lejona, María Eugenia Castelli, María Laura Cabeza, Linda Kenney, Eleonora García Véscovi, Fernando C. Soncini

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

Original languageEnglish (US)
Pages (from-to)2476-2480
Number of pages5
JournalJournal of Bacteriology
Volume186
Issue number8
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Fingerprint

Phosphorylation
Salmonella enterica
Magnesium
Genes
Up-Regulation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E., & Soncini, F. C. (2004). PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner. Journal of Bacteriology, 186(8), 2476-2480. https://doi.org/10.1128/JB.186.8.2476-2480.2004

PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner. / Lejona, Sergio; Castelli, María Eugenia; Cabeza, María Laura; Kenney, Linda; García Véscovi, Eleonora; Soncini, Fernando C.

In: Journal of Bacteriology, Vol. 186, No. 8, 01.04.2004, p. 2476-2480.

Research output: Contribution to journalArticle

Lejona, S, Castelli, ME, Cabeza, ML, Kenney, L, García Véscovi, E & Soncini, FC 2004, 'PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner', Journal of Bacteriology, vol. 186, no. 8, pp. 2476-2480. https://doi.org/10.1128/JB.186.8.2476-2480.2004
Lejona S, Castelli ME, Cabeza ML, Kenney L, García Véscovi E, Soncini FC. PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner. Journal of Bacteriology. 2004 Apr 1;186(8):2476-2480. https://doi.org/10.1128/JB.186.8.2476-2480.2004
Lejona, Sergio ; Castelli, María Eugenia ; Cabeza, María Laura ; Kenney, Linda ; García Véscovi, Eleonora ; Soncini, Fernando C. / PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner. In: Journal of Bacteriology. 2004 ; Vol. 186, No. 8. pp. 2476-2480.
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