PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Sergio Lejona, María Eugenia Castelli, María Laura Cabeza, Linda J. Kenney, Eleonora García Véscovi, Fernando C. Soncini

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

Original languageEnglish (US)
Pages (from-to)2476-2480
Number of pages5
JournalJournal of bacteriology
Issue number8
StatePublished - Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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