PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner

Sergio Lejona, María Eugenia Castelli, María Laura Cabeza, Linda Kenney, Eleonora García Véscovi, Fernando C. Soncini

Research output: Contribution to journalArticle

43 Scopus citations


The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.

Original languageEnglish (US)
Pages (from-to)2476-2480
Number of pages5
JournalJournal of Bacteriology
Issue number8
StatePublished - Apr 1 2004
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Lejona, S., Castelli, M. E., Cabeza, M. L., Kenney, L., García Véscovi, E., & Soncini, F. C. (2004). PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner. Journal of Bacteriology, 186(8), 2476-2480.