TY - JOUR
T1 - PhoP Can Activate Its Target Genes in a PhoQ-Independent Manner
AU - Lejona, Sergio
AU - Castelli, María Eugenia
AU - Cabeza, María Laura
AU - Kenney, Linda J.
AU - García Véscovi, Eleonora
AU - Soncini, Fernando C.
PY - 2004/4
Y1 - 2004/4
N2 - The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
AB - The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
UR - https://www.scopus.com/pages/publications/1842454278
UR - https://www.scopus.com/pages/publications/1842454278#tab=citedBy
U2 - 10.1128/JB.186.8.2476-2480.2004
DO - 10.1128/JB.186.8.2476-2480.2004
M3 - Article
C2 - 15060051
AN - SCOPUS:1842454278
SN - 0021-9193
VL - 186
SP - 2476
EP - 2480
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 8
ER -