Phospholipase A2-activating protein - An important regulatory molecule in modulating cyclooxygenase-2 and tumor necrosis factor production during inflammation

Deborah A. Ribardo, Johnny Peterson, Ashok Chopra

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Inflammation is a complex multifactorial process and a hallmark of many inflammatory diseases. Most of the tissue destruction that occurs in these diseases is the result of an aberrant or often uncontrolled immune response. Factors that play an important role in such diseases include pro-inflammatory cytokines, complement, and eicosanoids. This review focuses on eicosanoids and their regulation via phospholipase A2-activating protein, which could be targeted as a new therapeutic tool to control inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalIndian Journal of Experimental Biology
Volume40
Issue number2
StatePublished - 2002

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Cyclooxygenase 2
Eicosanoids
Tumor Necrosis Factor-alpha
Inflammation
Proteins
Molecules
Disease control
Tissue
Cytokines
phospholipase A2-activating protein
Prostaglandin-Endoperoxide Synthases
Therapeutics

ASJC Scopus subject areas

  • Bioengineering

Cite this

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