Phosphorylation of soluble guanylyl cyclase by the cyclic AMP-dependent protein kinase (PKA)

Anastasia Pyriochou, Antonis Tsarbopoulos, Andreas Papapetropoulos

Research output: Contribution to journalArticle


Soluble guanylyl cyclase (sGC) has been shown to be regulated by transcriptional, post-transcriptional and post-translational mechanisms. Post-translationally sGC activity and subcellular localization is regulated by both phosphorylation and protein-protein interactions. The aim of the present study was to determine whether sGC is a cAMP-dependent protein kinase (PKA) substrate. We provide evidence that both of and β1 sGC can be phosphorylated by PKA.

Original languageEnglish (US)
Pages (from-to)311-313
Number of pages3
JournalReview of Clinical Pharmacology and Pharmacokinetics, International Edition
Issue number2
StatePublished - Jun 6 2006
Externally publishedYes



  • cAMP-dependent protein kinase
  • cGMP
  • Phosphorylation
  • Soluble guanylyl cyclase

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this