Phosphorylation profiling and the understanding of viral pathogenesis

G. C. Bowick, N. K. Herzog

Research output: Contribution to journalArticle

Abstract

Viruses are dependent on their host cell for replication; this leads to an intimate interaction between the virus and the host. Viruses must evade the immune response, while simultaneously ensuring that the cellular processes required for replication are maintained. To this end, virus infection results in many changes in host-cell signalling networks, some subtle and some extreme. Many of these changes in signalling are at the level of protein phosphorylation. In this review, we discuss how understanding viral disease at the level of host signalling allows the molecular mechanisms of pathogenesis to be delineated, and how this understanding may lead to the development of novel therapeutics. In particular, we focus on the role of phosphorylation in these signalling networks.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalBio Tech International
Volume20
Issue number1
StatePublished - Feb 2008

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Phosphorylation
Virus Diseases
Viruses
Proteins
Therapeutics

ASJC Scopus subject areas

  • Biotechnology

Cite this

Phosphorylation profiling and the understanding of viral pathogenesis. / Bowick, G. C.; Herzog, N. K.

In: Bio Tech International, Vol. 20, No. 1, 02.2008, p. 12-16.

Research output: Contribution to journalArticle

Bowick, GC & Herzog, NK 2008, 'Phosphorylation profiling and the understanding of viral pathogenesis', Bio Tech International, vol. 20, no. 1, pp. 12-16.
Bowick, G. C. ; Herzog, N. K. / Phosphorylation profiling and the understanding of viral pathogenesis. In: Bio Tech International. 2008 ; Vol. 20, No. 1. pp. 12-16.
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