Photoperiod influences the growth of colon cancer in mice

Ron D. Waldrop; Rami Saydjari; Norma H. Rubin; Phillip L. Rayford; Courtney M. Townsend; James C. Thompson

doi:10.1016/0024-3205(89)90093-3

Photoperiod influences the growth of colon cancer in mice

Ron D. Waldrop, Rami Saydjari, Norma H. Rubin, Phillip L. Rayford, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.

Original language	English (US)
Pages (from-to)	737-744
Number of pages	8
Journal	Life Sciences
Volume	45
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(89)90093-3
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(89)90093-3

Cite this

@article{cb3f9836437d43abacaa352f93e85f49,

title = "Photoperiod influences the growth of colon cancer in mice",

abstract = "We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.",

author = "Waldrop, {Ron D.} and Rami Saydjari and Rubin, {Norma H.} and Rayford, {Phillip L.} and Townsend, {Courtney M.} and Thompson, {James C.}",

year = "1989",

doi = "10.1016/0024-3205(89)90093-3",

language = "English (US)",

volume = "45",

pages = "737--744",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Photoperiod influences the growth of colon cancer in mice

AU - Waldrop, Ron D.

AU - Saydjari, Rami

AU - Rubin, Norma H.

AU - Rayford, Phillip L.

AU - Townsend, Courtney M.

AU - Thompson, James C.

PY - 1989

Y1 - 1989

N2 - We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.

AB - We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.

UR - http://www.scopus.com/inward/record.url?scp=0024321089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024321089&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(89)90093-3

DO - 10.1016/0024-3205(89)90093-3

M3 - Article

C2 - 2506401

AN - SCOPUS:0024321089

SN - 0024-3205

VL - 45

SP - 737

EP - 744

JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Photoperiod influences the growth of colon cancer in mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this