Photoperiod influences the growth of colon cancer in mice

Ron D. Waldrop, Rami Saydjari, Norma H. Rubin, Phillip L. Rayford, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.

Original languageEnglish (US)
Pages (from-to)737-744
Number of pages8
JournalLife Sciences
Volume45
Issue number8
DOIs
StatePublished - 1989

Fingerprint

Photoperiod
Colonic Neoplasms
Tumors
Darkness
Growth
Tumor Burden
Eflornithine
Light
Neoplasms
Growth Inhibitors
Tumor Cell Line
Colon
Adenocarcinoma
Cells
Mortality

ASJC Scopus subject areas

  • Pharmacology

Cite this

Waldrop, R. D., Saydjari, R., Rubin, N. H., Rayford, P. L., Townsend, C., & Thompson, J. C. (1989). Photoperiod influences the growth of colon cancer in mice. Life Sciences, 45(8), 737-744. https://doi.org/10.1016/0024-3205(89)90093-3

Photoperiod influences the growth of colon cancer in mice. / Waldrop, Ron D.; Saydjari, Rami; Rubin, Norma H.; Rayford, Phillip L.; Townsend, Courtney; Thompson, James C.

In: Life Sciences, Vol. 45, No. 8, 1989, p. 737-744.

Research output: Contribution to journalArticle

Waldrop, RD, Saydjari, R, Rubin, NH, Rayford, PL, Townsend, C & Thompson, JC 1989, 'Photoperiod influences the growth of colon cancer in mice', Life Sciences, vol. 45, no. 8, pp. 737-744. https://doi.org/10.1016/0024-3205(89)90093-3
Waldrop, Ron D. ; Saydjari, Rami ; Rubin, Norma H. ; Rayford, Phillip L. ; Townsend, Courtney ; Thompson, James C. / Photoperiod influences the growth of colon cancer in mice. In: Life Sciences. 1989 ; Vol. 45, No. 8. pp. 737-744.
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