Photoperiod influences the growth of colon cancer in mice

Ron D. Waldrop, Rami Saydjari, Norma H. Rubin, Phillip L. Rayford, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We have developed a mouse colon adenocarcinoma cell line that produces tumors in a dose-dependent manner when injected subcutaneously. Our previous work has demonstrated its sequential pattern of tumor area and weight under 12L:12D (12 hours light, 12 hours darkness) photoperiod. This study investigated whether shorter (6L:18D) or longer (18L:6D) photoperiods alter tumor growth. Significantly greater tumor area, weight, and group mortality were found in mice exposed to 12L:12D photoperiods as compared to either 6L:18D or 18L:6D photoperiods, and difluoromethylornithine (DFMO) was a more effective inhibitor of tumor growth under the if6L:18D photoperiod compared to 12L:12D. These results demonstrate an important role of photoperiod on tumor growth.

Original languageEnglish (US)
Pages (from-to)737-744
Number of pages8
JournalLife Sciences
Volume45
Issue number8
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Waldrop, R. D., Saydjari, R., Rubin, N. H., Rayford, P. L., Townsend, C. M., & Thompson, J. C. (1989). Photoperiod influences the growth of colon cancer in mice. Life Sciences, 45(8), 737-744. https://doi.org/10.1016/0024-3205(89)90093-3