Phylogenetic analysis of alphaviruses in the venezuelan equine encephalitis complex and identification of the source of epizootic viruses

Scott Weaver, Liz Anne Bellew, Rebeca Rico-Hesse

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

We studied the evolution of alphaviruses in the Venezuelan equine encephalitis (VEE) complex using phylogenetic analysis of RNA nucleotide sequences from limited portions of the nsP4, El, and 3′ untranslated genome regions of representative strains. The VEE complex constituted a monophyletic group of viruses (descended from a common ancestor); some serologic VEE varieties such as subtype III formed monophyletic groups while subtype I did not. Subtype II Everglades and variety ID enzootic viruses formed a monophyletic group which also included all epizootic variety IAB and IC VEE isolates. Everglades virus diverged from this ID lineage (colonized North America) ca. 100-150 years ago, followed by divergence of variety IAB and IC epizootic viruses. Variety IAB viruses probably emerged from the variety ID lineage once during the early part of this century, while variety IC viruses evolved at least two times. These results identify the source of epizootic VEE viruses as the variety ID enzootic virus lineage which occurs in northern South America and Panama. Even if variety IAB and IC viruses are extinct, recent, multiple emergences of epizootic viruses from an enzootic lineage suggests that other epizootic VEE viruses may evolve again in the future. The close genetic relationship of subtype II Everglades virus to the variety ID lineage also implies the potential for emergence of equine-virulent VEE viruses in Florida.

Original languageEnglish (US)
Pages (from-to)282-290
Number of pages9
JournalVirology
Volume191
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Venezuelan Equine Encephalomyelitides
Alphavirus
Viruses
Venezuelan Equine Encephalitis Viruses
North America
Panama
South America
3' Untranslated Regions
Horses

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Phylogenetic analysis of alphaviruses in the venezuelan equine encephalitis complex and identification of the source of epizootic viruses. / Weaver, Scott; Bellew, Liz Anne; Rico-Hesse, Rebeca.

In: Virology, Vol. 191, No. 1, 1992, p. 282-290.

Research output: Contribution to journalArticle

@article{57f0b2810f264474b0c141cee808ecdd,
title = "Phylogenetic analysis of alphaviruses in the venezuelan equine encephalitis complex and identification of the source of epizootic viruses",
abstract = "We studied the evolution of alphaviruses in the Venezuelan equine encephalitis (VEE) complex using phylogenetic analysis of RNA nucleotide sequences from limited portions of the nsP4, El, and 3′ untranslated genome regions of representative strains. The VEE complex constituted a monophyletic group of viruses (descended from a common ancestor); some serologic VEE varieties such as subtype III formed monophyletic groups while subtype I did not. Subtype II Everglades and variety ID enzootic viruses formed a monophyletic group which also included all epizootic variety IAB and IC VEE isolates. Everglades virus diverged from this ID lineage (colonized North America) ca. 100-150 years ago, followed by divergence of variety IAB and IC epizootic viruses. Variety IAB viruses probably emerged from the variety ID lineage once during the early part of this century, while variety IC viruses evolved at least two times. These results identify the source of epizootic VEE viruses as the variety ID enzootic virus lineage which occurs in northern South America and Panama. Even if variety IAB and IC viruses are extinct, recent, multiple emergences of epizootic viruses from an enzootic lineage suggests that other epizootic VEE viruses may evolve again in the future. The close genetic relationship of subtype II Everglades virus to the variety ID lineage also implies the potential for emergence of equine-virulent VEE viruses in Florida.",
author = "Scott Weaver and Bellew, {Liz Anne} and Rebeca Rico-Hesse",
year = "1992",
doi = "10.1016/0042-6822(92)90190-Z",
language = "English (US)",
volume = "191",
pages = "282--290",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Phylogenetic analysis of alphaviruses in the venezuelan equine encephalitis complex and identification of the source of epizootic viruses

AU - Weaver, Scott

AU - Bellew, Liz Anne

AU - Rico-Hesse, Rebeca

PY - 1992

Y1 - 1992

N2 - We studied the evolution of alphaviruses in the Venezuelan equine encephalitis (VEE) complex using phylogenetic analysis of RNA nucleotide sequences from limited portions of the nsP4, El, and 3′ untranslated genome regions of representative strains. The VEE complex constituted a monophyletic group of viruses (descended from a common ancestor); some serologic VEE varieties such as subtype III formed monophyletic groups while subtype I did not. Subtype II Everglades and variety ID enzootic viruses formed a monophyletic group which also included all epizootic variety IAB and IC VEE isolates. Everglades virus diverged from this ID lineage (colonized North America) ca. 100-150 years ago, followed by divergence of variety IAB and IC epizootic viruses. Variety IAB viruses probably emerged from the variety ID lineage once during the early part of this century, while variety IC viruses evolved at least two times. These results identify the source of epizootic VEE viruses as the variety ID enzootic virus lineage which occurs in northern South America and Panama. Even if variety IAB and IC viruses are extinct, recent, multiple emergences of epizootic viruses from an enzootic lineage suggests that other epizootic VEE viruses may evolve again in the future. The close genetic relationship of subtype II Everglades virus to the variety ID lineage also implies the potential for emergence of equine-virulent VEE viruses in Florida.

AB - We studied the evolution of alphaviruses in the Venezuelan equine encephalitis (VEE) complex using phylogenetic analysis of RNA nucleotide sequences from limited portions of the nsP4, El, and 3′ untranslated genome regions of representative strains. The VEE complex constituted a monophyletic group of viruses (descended from a common ancestor); some serologic VEE varieties such as subtype III formed monophyletic groups while subtype I did not. Subtype II Everglades and variety ID enzootic viruses formed a monophyletic group which also included all epizootic variety IAB and IC VEE isolates. Everglades virus diverged from this ID lineage (colonized North America) ca. 100-150 years ago, followed by divergence of variety IAB and IC epizootic viruses. Variety IAB viruses probably emerged from the variety ID lineage once during the early part of this century, while variety IC viruses evolved at least two times. These results identify the source of epizootic VEE viruses as the variety ID enzootic virus lineage which occurs in northern South America and Panama. Even if variety IAB and IC viruses are extinct, recent, multiple emergences of epizootic viruses from an enzootic lineage suggests that other epizootic VEE viruses may evolve again in the future. The close genetic relationship of subtype II Everglades virus to the variety ID lineage also implies the potential for emergence of equine-virulent VEE viruses in Florida.

UR - http://www.scopus.com/inward/record.url?scp=0026786096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026786096&partnerID=8YFLogxK

U2 - 10.1016/0042-6822(92)90190-Z

DO - 10.1016/0042-6822(92)90190-Z

M3 - Article

VL - 191

SP - 282

EP - 290

JO - Virology

JF - Virology

SN - 0042-6822

IS - 1

ER -